Effect of bone matrix-derived growth factors on skull and tibia in the growing rat.

Effect of bone matrix-derived growth factors on skull and tibia in the growing rat. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of bone matrix-derived growth factors on skull and tibia in the growing rat. Abstract Text:

C ,J Jennings,M Lundy,D J Baylink,

Aberration in cranial skeletal morphology during growth due to metabolic bone diseases associated with hypocalcemia is related to abnormalities in cranial suture growth. It was found in previous experimental studies that a changed cranial growth pattern induced by hypocalcemia and secondary hyperparathyroidism was dependent on a decreased bone apposition in viscerocranial growth sites. Of interest was the observation that obliterative osteogenesis occurred with this disturbance. In vitro studies have shown that when bone resorption is stimulated by parathyroid hormone, mitogenic factors for bone cells are released from the matrix. The aim of the current study was to elucidate a possible local regulatory mechanism for bone growth especially with regard to cranial growth. Two groups of young rats were injected daily with 150 micrograms and 750 micrograms respectively of bone matrix-derived growth factor preparation (BMDGF) for 2 weeks. By using cephalometric analysis, the BMDGF administration was shown to alter skull morphology during growth. Since the high doses of BMDGF caused markedly more changes than the low dose, the overall effect on craniofacial growth seemed to be dose dependent. The high dose of BMDGF induced a decrease in cortical bone apposition found in this region, as well as in the diaphysis of the tibia. Also a change in position of the viscerocranium in relation to the cranial base was found in the BMDGF-treated rats: the flexure between the viscerocranium and the cranial base being greater compared with the normal skull. This change in relationship seemed to be related to the enhanced bone apposition found in the viscerocranial sutures of BMDGF-treated rats.(ABSTRACT TRUNCATED AT 250 WORDS)

Effect of bone matrix-derived growth factors on skull and tibia in the growing rat. Publishing Authors By Initials

C ,J Jennings,M Lundy,DJ Baylink,

For similar musculoskeletal system: skeleton: bone and bones: bones of lower extremity: leg bones: tibia research abstracts see: musculoskeletal system: skeleton: bone and bones: bones of lower extremity: leg bones: tibia research

PUBMED ID PMID:

MEDLINE DATE:

Effect of bone matrix-derived growth factors on skull and tibia in the growing rat. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of oral pathology

VOLUME: 17

Page Numbers: 334-40

Journal Abbreviation: J. Oral Pathol.

ISSN: 0300-9777

DAY: 18

MONTH: Aug

YEAR: 1988

Effect of bone matrix-derived growth factors on skull and tibia in the growing rat. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 342050

Effect of bone matrix-derived growth factors on skull and tibia in the growing rat. Keywords Mesh Terms:

KEYWORDS: Tibia

MESH TERMS: growth & development

Chemical & Substance for Abstract: Effect of bone matrix-derived growth factors on skull and tibia in the growing rat. Information

Substance Name: Calcium

Registry Number: 7440-70-2

Grant and Affiliation Information for Effect of bone matrix-derived growth factors on skull and tibia in the growing rat.

AFFILIATION: Mineral Metabolism Unit, Veterans Administration Hospital, Loma Linda, California.

Country: DENMARK

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Oral Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of bone matrix-derived growth factors on skull and tibia in the growing rat Related Publications

• ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts.
• Bone-derived factors active on bone cells.
• Bovine skeletal growth factor stimulates protein phosphorylation of chicken bone cells in vitro.
• Characterization of cells isolated and cultured from human bone.
• Chemical and biological characterization of low-molecular-weight human skeletal growth factor.
• Effect of bone matrix-derived growth factors on skull and tibia in the growing rat.
• Human skeletal growth factor stimulates collagen synthesis and inhibits proliferation in a clonal osteoblast cell line (MC3T3-E1).
• Human skeletal growth factor: characterization of the mitogenic effect on bone cells in vitro.
• In vitro metabolism of 25-hydroxyvitamin D3 by isolated rat kidney cells.
• Isolation and purification of a low-molecular-weight skeletal growth factor from human bones.
• Primary structure of human skeletal growth factor: homology with human insulin-like growth factor-II.
• Purification of a skeletal growth factor from human bone.
• Purification of bovine skeletal growth factor.
• Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat.
• Sca-1(+) hematopoietic cell-based gene therapy with a modified FGF-2 increased endosteal/trabecular bone formation in mice.
• Skeletal growth factor and other growth factors known to be present in bone matrix stimulate proliferation and protein synthesis in human bone cells.
• Skeletal growth factor is produced by human osteoblast-like cells in culture.
• The diagnosis of osteoporosis.
• The renal metabolism of 25-hydroxyvitamin D3 in the rat: regulation by 1,25-dihydroxyvitamin D3.
• Vanadate stimulates bone cell proliferation and bone collagen synthesis in vitro.