Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women.

Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women. Research Abstract Details 

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Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women. Abstract Text:

Francine K Welty,Alice H Lichtenstein,Stefania Lamon-Fava,Ernst J Schaefer,Julian B Marsh,

The effect of body mass index (BMI) and obesity on apolipoprotein (apo) A-I levels and kinetics was examined by gender. Apo A-I kinetics were determined with a primed, constant infusion of deuterated leucine in the fed state in 19 men and 13 postmenopausal women. Compared with nonobese men, nonobese women had a higher level of high-density lipoprotein cholesterol (HDL-C) and apo A-I due to a 48% higher apo A-I production rate (PR) (P = .05). Obesity had no significant effects on apo A-I kinetics in women. In contrast, compared with nonobese men, obese men had a 9% lower apo A-I level due to a 64% higher fractional catabolic rate (FCR) partially offset by a 47% higher PR. Obese women had a 52% higher HDL-C than obese men (50 vs 33 mg/dL, respectively; P = .012), a finding related to the faster apo A-I FCR in obese men. BMI was directly correlated with apo A-I FCR (r = 0.84, P < .001) and PR (r = 0.79, P < .001) in men but not in women. Sixty-two percent of the variability in PR and 71% of the variability in FCR were due to BMI in men and only 3% and 23%, respectively, in women. In conclusion, BMI has a significant effect on apo A-I PR and FCR in men but not in women.

Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women. Publishing Authors By Initials

FK Welty,AH Lichtenstein,S Lamon-Fava,EJ Schaefer,JB Marsh,

For similar reproductive and urinary physiology: reproduction: sexual development: climacteric: menopause: postmenopause research abstracts see: reproductive and urinary physiology: reproduction: sexual development: climacteric: menopause: postmenopause research

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Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Metabolism: clinical and experimental

VOLUME: 56

Page Numbers: 910-4

Journal Abbreviation: Metab. Clin. Exp.

ISSN: 0026-0495

DAY: 3

MONTH: Jul

YEAR: 2007

Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women. Information

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LANGUAGE: eng

NlmUniqueID: 375267

Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women. Keywords Mesh Terms:

KEYWORDS: Postmenopause

MESH TERMS: blood

Chemical & Substance for Abstract: Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women. Information

Substance Name: Cholesterol, HDL

Registry Number: 0

Grant and Affiliation Information for Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women.

AFFILIATION: Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. fwelty@bidmc.harvard.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL56895

ACRONYM: HL

MEDLINETA: Metabolism

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