Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes.

Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes. Abstract Text:

Farah D Khan,Piyush M Vyas,Anthony A Gaspari,Craig K Svensson,Farah D Khan,Piyush M Vyas,Anthony A Gaspari,Craig K Svensson,

The initiation of an immune response to small molecules is believed to require the release of stress/danger signals that activate resident dendritic cells, presumably secondary to the formation of reactive metabolites. We hypothesized that exposure to arylhydroxylamine metabolites of dapsone and sulfamethoxazole lead to the expression/release of numerous stress signals in the skin. To test this hypothesis, we examined the effect of these metabolites on the expression of selected heat shock proteins, uric acid, cytokines, adhesion molecules, and costimulatory molecules in normal human epidermal keratinocytes (NHEKs). NHEKs showed a time-dependent up-regulation of heat shock protein 70 and translocation of heat shock protein 27 when exposed to the arylhydroxylamine metabolites. In addition, the secretion of several proinflammatory cytokines was increased upon incubation of these cells with metabolite. In contrast, the uric acid concentration was not altered. Moreover, intercellular adhesion molecule-1, CD80, and CD86 expressions did not change when NHEKs were exposed to these reactive metabolites. Our data suggest that NHEKs selectively up-regulate certain danger signals when exposed to arylhydroxylamine metabolites. These signals may subsequently activate dendritic cells and initiate an immune response within skin.

Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes. Publishing Authors By Initials

FD Khan,PM Vyas,AA Gaspari,CK Svensson,FD Khan,PM Vyas,AA Gaspari,CK Svensson,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of pharmacology and experimental thera

VOLUME: 323

Page Numbers: 771-7

Journal Abbreviation: J. Pharmacol. Exp. Ther.

ISSN: 1521-0103

DAY: 31

MONTH: 08

YEAR: 2007

Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376362

Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes.

AFFILIATION: Division of Pharmaceutics, The University of Iowa, Iowa City, Iowa, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM63821

ACRONYM: GM

MEDLINETA: J Pharmacol Exp Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes Related Publications

• Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity.
• Acute aortic syndromes: time to talk of many things.
• An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif.
• Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia.
• Central sensitization phenomena after third molar surgery: A quantitative sensory testing study.
• Denatured hemoproteins as catalysts in lipid oxidation.
• Determination of dextromethorphan and its metabolites in plasma by dual column liquid chromatography and fluorimetric detection.
• Dispatcher-assisted telephone-guided cardiopulmonary resuscitation: an underused lifesaving system.
• Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes.
• Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women.
• Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes.
• Effect of conditioning electrical stimuli on temporalis electromyographic activity during sleep.
• Effects of local anesthetics on somatosensory function in the temporomandibular joint area.
• Efficacy and safety of anticoagulant prophylaxis to prevent venous thromboembolism in acutely ill medical inpatients: a meta-analysis.
• FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart.
• Formation and uptake of arylhydroxylamine-haptenated proteins in human dendritic cells.
• General intellectual capacity of young men with cleft lip with or without cleft palate and cleft palate alone.
• Human papillomavirus (HPV), DNA aberrations and cell cycle progression in anal squamous cell carcinoma patients.
• Hypersensitivity to Mechanical and Intra-articular Electrical Stimuli in Persons with Painful Temporomandibular Joints.
• Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals.
• Spatio-temporal changes in germination and radical elongation of barley seeds tracked by proteome analysis of dissected embryo, aleurone layer, and endosperm tissues.
• Speech results in adult Swedish patients born with unilateral complete cleft lip and palate.
• Survival is similar after standard treatment and chest compression only in out-of-hospital bystander cardiopulmonary resuscitation.
• The 'pair of sugar tongs' site on the non-catalytic domain C of barley alpha-amylase participates in substrate binding and activity.
• The Second JOR Summer School Review Series.
• The impact of pain and depression on assessment of rehabilitation need: a cross-sectional study in long-term sick-listed patients.
• Vagal influences on gastric acid secretion. Experimental studies in cats.
• Vertical structure of recent Arctic warming.
• [In Process Citation]
• [Not Available.]