[Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells(HepG2)]

[Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells(HepG2)] Research Abstract Details 

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[Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells(HepG2)] Abstract Text:

Junxia Min,Junsheng Guo,Faji Zhao,Donglian Cai,

To observe the effect of apoptosis induced by alpha-tocopherol(alpha-T), gamma-tocopherol(gamma-T), delta-tocopherol(delta-T), and vitamin E succinate (VES) in human hepatoma cells (HepG2), apoptosis was detected by flow cytometry (FCM) and DNA ladder with different VE homologues analogues (alpha-T, gamma-T, delta-T and VES) and different concentrations (12.5 mg/L, 25 mg/L, 50 mg/L, 100 mg/L and 200 mg/L) at 48 h. The growth of HepG2 cells was inhibited by delta-T and VES at 12.5-200 mg/L in comparison with the negative control group, while (-T showed weak effect of inhibition and alpha-T did not show any inhibition effect. However, as an exception, alpha-tocopherol, delta-tocopherol and VES were effective in induction of apoptosis in HepG2 cells at concentrations of 12.5-200 mg/L. gamma-tocopherol showed effect only at 200 mg/L. Conclusions delta-tocopherol and VES lowered HepG2 cells growth and viability, and increased apoptotic propensity significantly. A dose-dependent of antiproliferation and induction apoptosis was found in HepG2 cells line. The order of efficiency of four vitamin E analogues was delta-tocopherol > VES > gamma-tocopherol > alpha-tocopherol. The difference in nature and magnitude of the anticancer effects did not correlate with their reported antioxidant activity and this might be due to minor differences in their structure important to their biological activities. The results from this study suggested that delta-tocopherol and VES could be the promising anti-hepatoma agents.

[Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells(HepG2)] Publishing Authors By Initials

J Min,J Guo,F Zhao,D Cai,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: gamma-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: gamma-tocopherol research

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[Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells(HepG2)] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Wei sheng yan jiu = Journal of hygiene research

VOLUME: 32

Page Numbers: 343-5

Journal Abbreviation:

ISSN: 1000-8020

DAY: 19

MONTH: Jul

YEAR: 2003

[Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells(HepG2)] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 9426367

[Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells(HepG2)] Keywords Mesh Terms:

KEYWORDS: gamma-Tocopherol

MESH TERMS: pharmacology

Chemical & Substance for Abstract: [Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells(HepG2)] Information

Substance Name: alpha-Tocopherol

Registry Number: 59-02-9

Grant and Affiliation Information for [Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells(HepG2)]

AFFILIATION: Second Military Medical University, Shanghai 200433, China.

Country: China

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MEDLINETA: Wei Sheng Yan Jiu

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