Effect of antimalarial drugs on human neutrophil chemotaxis in vitro.

Effect of antimalarial drugs on human neutrophil chemotaxis in vitro. Research Abstract Details 

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Effect of antimalarial drugs on human neutrophil chemotaxis in vitro. Abstract Text:

The effect of several antimalarial drugs, commonly used for prophylaxis and therapy of human malaria, on polymorphonuclear leukocyte chemotaxis was studied. A modified, reversible Boyden chamber method was used. Various concentrations of each drug was mixed with neutrophils and incubated in the chambers for 2 1/2 hours. After the incubation period percent inhibition of chemotaxis was determined. It was shown that chloroquine, quinine, proguanil, and tetracycline at concentrations frequently obtained in clinical situations significantly inhibited chemotaxis of neutrophils towards casein. There was a direct correlation between increasing drug concentration and percent inhibition of chemotaxis. Drugs such as pyrimethamine and fansidar at any concentration tested had no effect on chemotaxis.

Effect of antimalarial drugs on human neutrophil chemotaxis in vitro. Publishing Authors By Initials

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: triazines research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: triazines research

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Effect of antimalarial drugs on human neutrophil chemotaxis in vitro. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta pathologica, microbiologica, et immunologica

VOLUME: 91

Page Numbers: 293-8

Journal Abbreviation:

ISSN: 0108-0202

DAY: 26

MONTH: Aug

YEAR: 1983

Effect of antimalarial drugs on human neutrophil chemotaxis in vitro. Information

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LANGUAGE: eng

NlmUniqueID: 8206624

Effect of antimalarial drugs on human neutrophil chemotaxis in vitro. Keywords Mesh Terms:

KEYWORDS: Triazines

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effect of antimalarial drugs on human neutrophil chemotaxis in vitro. Information

Substance Name: Tetracycline

Registry Number: 60-54-8

Grant and Affiliation Information for Effect of antimalarial drugs on human neutrophil chemotaxis in vitro.

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Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Immunol

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