Effect of antibodies to morphine in ultralow doses on induction of long-term potentiation in hippocampal slices from rats with chronic morphine dependence.

Effect of antibodies to morphine in ultralow doses on induction of long-term potentiation in hippocampal slices from rats with chronic morphine dependence. Research Abstract Details 

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Effect of antibodies to morphine in ultralow doses on induction of long-term potentiation in hippocampal slices from rats with chronic morphine dependence. Abstract Text:

N A Beregovoi,N S Sorokina,M V Starostina,M B Shtark,O I Epstein,

Antibodies to morphine produced after its chronic administration can contribute to changes in the central nervous system during opiate abuse. Facilitation of long-term posttetanic potentiation in mossy fibers of the hippocampus in rats with chronic morphine dependence can be reproduced in hippocampal slices from normal animals treated with antibodies to morphine. Incubation of hippocampal slices with ultralow doses of antibodies to morphine had no effect on control rats, but reduced facilitation of long-term potentiation in hippocampal slices from animals with chronic morphine dependence. This confirms the possibility of using ultralow doses of antibodies to morphine for therapeutic correction of mechanisms underlying the formation of drug abuse.

Effect of antibodies to morphine in ultralow doses on induction of long-term potentiation in hippocampal slices from rats with chronic morphine dependence. Publishing Authors By Initials

NA Beregovoi,NS Sorokina,MV Starostina,MB Shtark,OI Epstein,

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Effect of antibodies to morphine in ultralow doses on induction of long-term potentiation in hippocampal slices from rats with chronic morphine dependence. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bulletin of experimental biology and medicine

VOLUME: 135 Suppl 1

Page Numbers: 26-8

Journal Abbreviation: Bull. Exp. Biol. Med.

ISSN: 0007-4888

DAY: 1

MONTH: 09

YEAR: 2003

Effect of antibodies to morphine in ultralow doses on induction of long-term potentiation in hippocampal slices from rats with chronic morphine dependence. Information

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LANGUAGE: eng

NlmUniqueID: 372557

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AFFILIATION: Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk; "Materia Medica Holding" Research-and-Production Company, Moscow.

Country: United States

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