[Effect of alginate purity on microencapsulated hepatocyte overgrowth in peritoneal transplantation]

[Effect of alginate purity on microencapsulated hepatocyte overgrowth in peritoneal transplantation] Research Abstract Details 

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[Effect of alginate purity on microencapsulated hepatocyte overgrowth in peritoneal transplantation] Abstract Text:

C Yu,X Leng,Y Wei,J Liu,R Du,

OBJECTION: To study the effect of alginate purity on micro-encapsule overgrowth in peritoneal transplantation. METHODS: Alginate was purified by filtration and chloroform/butanol extraction. Using purified and crude alginate to make two kinds of microencapsulated hepatocytes (MHs), we transplanted 5 ml of each kind of MHs into the peritoneal cavities of rats. After 2 weeks, 1, 2, and 6 months, MHs were washed out to study overgrowth of MH, histology, enzyme and albumin of hepatocytes. Human lymphocytes transformation was measured by 3H-TdR incorporation with two kinds of alginate solutions. RESULTS: The amount of retrieved MHs was larger in the purified than in the crude ( P < 0.01). In the purified groups, most hepatocytes had normal features of morphology, enzymatic histochemistry, and albumin immunohistochemistry staining after one month of transplantation, but were damaged in the crude groups only 2 weeks later. Micro-encapsules were smooth, regular and had no overgrowth during 6 months in the purified but overgrowth one month later after transplantation in the crude. The liquid scintillation counting (cpm) was lower in the purified than in the crude. CONCLUSION: The purified alginate could reduce the overgrowth of MH and improve the function of hepatocytes significantly.

[Effect of alginate purity on microencapsulated hepatocyte overgrowth in peritoneal transplantation] Publishing Authors By Initials

C Yu,X Leng,Y Wei,J Liu,R Du,

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[Effect of alginate purity on microencapsulated hepatocyte overgrowth in peritoneal transplantation] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery

VOLUME: 38

Page Numbers: 300-2, 19

Journal Abbreviation: Zhonghua Wai Ke Za Zhi

ISSN: 0529-5815

DAY: 26

MONTH: Apr

YEAR: 2000

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LANGUAGE: chi

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AFFILIATION: Department of Surgery, People's Hospital, Beijing Medical University, China.

Country: China

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MEDLINETA: Zhonghua Wai Ke Za Zhi

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