Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha- dendritic cell function.

Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha- dendritic cell function. Research Abstract Details 

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Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha- dendritic cell function. Abstract Text:

Annabelle Grolleau-Julius,Monika R Garg,Ruran Mo,Lloyd L Stoolman,Raymond L Yung,

Dendritic cells (DCs) are actively used as cellular adjuvant in cancer immunotherapy. However, although DC immunotherapies primarily target the elderly population, little is known about the effect of aging on DC functions. Here, we compared the T-cell stimulation, cytokine production, and tumor surveillance functions of bone marrow-derived CD11c(+)CD4(-)CD8alpha(-) DCs of old and young C57BL/6 mice. Old immature bone marrow-derived CD4(-)CD8alpha(-) DCs (imDCs) were 4 times less effective than were young DCs in stimulating syngeneic CD4(+) T-cell proliferation. Old imDCs also have decreased DC-specific/intracellular adhesion molecule type 3-grabbing, nonintegrin (DC-SIGN) expression compared to young DCs. Interestingly, mice treated with the ovalbumin peptide-pulsed young DCs exhibited significantly greater tumor regression than with ovalbumin peptide-pulsed old DCs. Old terminally differentiated bone marrow-derived DCs (tDC) also have increased interleukin-10, but decreased interleukin-6 and tumor necrosis factor-alpha production. Taken together, these results have important implications in the clinical application of DC-based tumor immunotherapy in elderly persons.

Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha- dendritic cell function. Publishing Authors By Initials

A Grolleau-Julius,MR Garg,R Mo,LL Stoolman,RL Yung,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha- dendritic cell function. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The journals of gerontology. Series A, Biological

VOLUME: 61

Page Numbers: 1039-47

Journal Abbreviation: J. Gerontol. A Biol. Sci. Med.

ISSN: 1079-5006

DAY: 3

MONTH: Oct

YEAR: 2006

Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha- dendritic cell function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502837

Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha- dendritic cell function. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: immunology

Chemical & Substance for Abstract: Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha- dendritic cell function. Information

Substance Name: Receptors, Cell Surface

Registry Number: 0

Grant and Affiliation Information for Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha- dendritic cell function.

AFFILIATION: Room 5312 CCGC, 1500 East Medical Center Drive, Ann Arbor, Michigan, 48109-0940, USA.

Country: United States

AGENCY: United States NIAID

GRANT: 1R01 AI42753

ACRONYM: AI

MEDLINETA: J Gerontol A Biol Sci Med Sci

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