Effect of age on the response to in vitro ischemia and reperfusion of the rabbit bladder.

Effect of age on the response to in vitro ischemia and reperfusion of the rabbit bladder. Research Abstract Details 

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Effect of age on the response to in vitro ischemia and reperfusion of the rabbit bladder. Abstract Text:

Canan Aldirmaz Agartan,Robert E Leggett,Barry A Kogan,Robert M Levin,

BACKGROUND/AIMS: Urinary bladder dysfunction secondary to outlet obstruction is a common condition, seen in both children and adults. Using in vitro models of ischemia/reperfusion (I/R), we compared the contractile and biochemical responses of bladders isolated from young and old rabbits. MATERIALS AND METHODS: Fourteen male New Zealand White rabbits were separated into two groups of 7. Group 1 (young) included rabbits 6-7 weeks old and group 2 (old) consisted of rabbits 2 years old. Isolated bladder body strips were subjected to in vitro I/R, and the effects on contractility were determined. The strips were then frozen and stored for quantitative malondialdehyde (MDA) analysis. RESULTS: Contractile responses of young and old rabbit bladders to all forms of stimulation--field stimulation (FS), carbachol and potassium chloride (KCl)--were equal. The rate of tension to 32 Hz FS was significantly higher for group 1 in comparison with group 2. The old and young rabbits were equally sensitive to I/R in regard to FS, but the old rabbits were more sensitive to I/R in regard to carbachol and KCl stimulation. Basal MDA concentration of both young and aged bladder strips were similar. Ischemia mediated a significant increase in MDA in bladder strips from both young and old rabbits, but the MDA level was significantly greater for the young than for the old. CONCLUSION: Although the level of oxidative damage was greater in the young rabbit bladders, functionally, the old rabbit bladders were more sensitive to I/R damage.

Effect of age on the response to in vitro ischemia and reperfusion of the rabbit bladder. Publishing Authors By Initials

CA Agartan,RE Leggett,BA Kogan,RM Levin,

For similar urogenital system: urinary tract: urinary bladder research abstracts see: urogenital system: urinary tract: urinary bladder research

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Effect of age on the response to in vitro ischemia and reperfusion of the rabbit bladder. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Urologia internationalis

VOLUME: 78

Page Numbers: 155-9

Journal Abbreviation: Urol. Int.

ISSN: 0042-1138

DAY: 3

MONTH: 12

YEAR: 2007

Effect of age on the response to in vitro ischemia and reperfusion of the rabbit bladder. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 417373

Effect of age on the response to in vitro ischemia and reperfusion of the rabbit bladder. Keywords Mesh Terms:

KEYWORDS: Urinary Bladder

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Effect of age on the response to in vitro ischemia and reperfusion of the rabbit bladder. Information

Substance Name: Malondialdehyde

Registry Number: 542-78-9

Grant and Affiliation Information for Effect of age on the response to in vitro ischemia and reperfusion of the rabbit bladder.

AFFILIATION: Department of Urology, Albany Medical College, Albany, NY, USA. cananagartan@hotmail.com

Country: Switzerland

AGENCY: United States NIDDK

GRANT: R0-1-DK 067114

ACRONYM: DK

MEDLINETA: Urol Int

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