[Effect of adenosine on recovery of lowered viability of preserved rat hearts measured by 31P magnetic resonance spectroscopy]

[Effect of adenosine on recovery of lowered viability of preserved rat hearts measured by 31P magnetic resonance spectroscopy] Research Abstract Details 

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[Effect of adenosine on recovery of lowered viability of preserved rat hearts measured by 31P magnetic resonance spectroscopy] Abstract Text:

K Iwamoto,N Usui,H Kinoshita,

The restoration of the viability of rat hearts preserved for 5 hr by 50 microM adenosine (ADN) was evaluated in terms of the cardiac function after preservation and the recovery of myocardial high energy phosphates measured by 31P magnetic resonance spectroscopy. The hearts were perfused with modified Krebs-Ringer's solution (mKRS) with ADN (ADN group) or without AND (non-ADN group) for 1 hour after 5 hr of preservation by the simple immersion method. Control hearts were perfused but not preserved. ATP and phosphocreatine had decreased to 47.2 +/- 6.6% and 28.0 +/- 8.6% of the base line by 5 hr of preservation, but the levels returned to 147.2 +/- 2.3% and 127.4 +/- 5.6% after 1 hr of perfusion with ADN; at the same time, in the non-ADN group, they were 103.8 +/- 2.3% and 115.8 +/- 8.3% respectively. The same hearts were next perfused for 3 hr with standard Krebs-Ringer's solution so as to beat after the perfusion with mKRS. After 3 hr of beating, LV dP/dt was 3330 +/- 116 mmHg/s in the ADN group, which was not significantly different from the control (3034 +/- 60 mmHg/s). However, in the non-ADN group, the value was 2516 +/- 201 mmHg/s and significantly lower (p less than 0.05) than the control. The rate-pressure product was 19350 +/- 1154 in the ADN group, not significantly different from the control (20899 +/- 709), but it was 14559 +/- 1339 in the non-ADN group, which was significantly lower (p less than 0.01) than the control.(ABSTRACT TRUNCATED AT 250 WORDS)

[Effect of adenosine on recovery of lowered viability of preserved rat hearts measured by 31P magnetic resonance spectroscopy] Publishing Authors By Initials

K Iwamoto,N Usui,H Kinoshita,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: tissue survival research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: tissue survival research

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MEDLINE DATE:

[Effect of adenosine on recovery of lowered viability of preserved rat hearts measured by 31P magnetic resonance spectroscopy] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: [Zasshi] [Journal]. Nihon Ky?bu Geka Gakkai

VOLUME: 38

Page Numbers: 1270-7

Journal Abbreviation:

ISSN: 0369-4739

DAY: 14

MONTH: Aug

YEAR: 1990

[Effect of adenosine on recovery of lowered viability of preserved rat hearts measured by 31P magnetic resonance spectroscopy] Information

Number of References:

LANGUAGE: jpn

NlmUniqueID: 19130180

[Effect of adenosine on recovery of lowered viability of preserved rat hearts measured by 31P magnetic resonance spectroscopy] Keywords Mesh Terms:

KEYWORDS: Tissue Survival

MESH TERMS: drug effects

Chemical & Substance for Abstract: [Effect of adenosine on recovery of lowered viability of preserved rat hearts measured by 31P magnetic resonance spectroscopy] Information

Substance Name: Adenosine

Registry Number: 58-61-7

Grant and Affiliation Information for [Effect of adenosine on recovery of lowered viability of preserved rat hearts measured by 31P magnetic resonance spectroscopy]

AFFILIATION: Department of Surgery, Osaka City University Medical School, Japan.

Country: JAPAN

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MEDLINETA: Nippon Kyobu Geka Gakkai Zassh

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