Effect of activated protein C on pulmonary blood flow and cytokine production in experimental acute lung injury.

Effect of activated protein C on pulmonary blood flow and cytokine production in experimental acute lung injury. Research Abstract Details 

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Effect of activated protein C on pulmonary blood flow and cytokine production in experimental acute lung injury. Abstract Text:

Jean-Christophe Richard,Fabienne Bregeon, Leray,Didier Le Bars,Nicolas Costes,Christian Tourvieille,Franck Lavenne,Mojgan Devouassoux-Shisheboran,Gerard Gimenez,Claude Guerin,

OBJECTIVE: In acute lung injury (ALI) activated protein C (APC) may reopen occluded lung vessels and minimize lung inflammation. We aimed at assessing the effect of APC on regional lung perfusion, aerated lung volume, cytokine production and oxygenation in experimental ALI. DESIGN AND SETTING: Prospective, controlled study in an imaging facility. PARTICIPANTS: Pigs tracheotomized and mechanically ventilated. INTERVENTION: Pigs were randomly given intravenously APC (n[Symbol: see text]=[Symbol: see text]8) or saline (n[Symbol: see text]=[Symbol: see text]8). Thirty minutes later, ALI was induced by injecting oleic acid. MEASUREMENTS AND RESULTS: Lung perfusion and aerated lung volume measured with positron emission tomography, plasma cytokines and arterial blood gas were determined just before ALI and 110 and 290[Symbol: see text]min thereafter. Lung cytokines were measured at the end of the experiment. PaO(2) under F(I)O(2) 1 was significantly lower in the APC group before lung injury (473[Symbol: see text]+/-[Symbol: see text]129 vs. 578[Symbol: see text]+/-[Symbol: see text]54[Symbol: see text]mmHg) and 110[Symbol: see text]min (342[Symbol: see text]+/-[Symbol: see text]138 vs. 446[Symbol: see text]+/-[Symbol: see text]103[Symbol: see text]mmHg) and 290[Symbol: see text]min (303[Symbol: see text]+/-[Symbol: see text]171 vs. 547[Symbol: see text]+/-[Symbol: see text]54[Symbol: see text]mmHg) thereafter (p[Symbol: see text]<[Symbol: see text]0.05). Lung perfusion nonsignificantly tended to redistribute towards dorsal lung regions with APC. Total aerated lung volume was not different between APC and control before ALI (10.0[Symbol: see text]+/-[Symbol: see text]1.5 vs. 11.0[Symbol: see text]+/-[Symbol: see text]2.5 ml/kg) (p[Symbol: see text]>[Symbol: see text]0.05) or thereafter. Plasma IL-6 and IL-8 at 110[Symbol: see text]min were greater with APC (p[Symbol: see text]<[Symbol: see text]0.05). CONCLUSIONS: In contrast to studies using other models, pretreatment with APC was associated with worsening oxygenation in the present investigation. This might be due to ventilation-perfusion mismatch, with more perfusion to dependent nonaerated areas.

Effect of activated protein C on pulmonary blood flow and cytokine production in experimental acute lung injury. Publishing Authors By Initials

JC Richard,F Bregeon,V Leray,D Le Bars,N Costes,C Tourvieille,F Lavenne,M Devouassoux-Shisheboran,G Gimenez,C Guerin,

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Effect of activated protein C on pulmonary blood flow and cytokine production in experimental acute lung injury. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Intensive care medicine

VOLUME: 33

Page Numbers: 2199-206

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ISSN: 0342-4642

DAY: 2

MONTH: 08

YEAR: 2007

Effect of activated protein C on pulmonary blood flow and cytokine production in experimental acute lung injury. Information

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LANGUAGE: eng

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AFFILIATION: Service de Réanimation Médicale, Hôpital de la Croix Rousse, 103 Grande Rue de la Croix Rousse, 69004, Lyon, France.

Country: United States

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MEDLINETA: Intensive Care Med

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