[Effect of acrylamide on creatine kinase and adenosine triphosphate in brain of mice and its significance]

[Effect of acrylamide on creatine kinase and adenosine triphosphate in brain of mice and its significance] Research Abstract Details 

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[Effect of acrylamide on creatine kinase and adenosine triphosphate in brain of mice and its significance] Abstract Text:

Qiuyue He,Manfu Han,Mingli Rao,

OBJECTIVE: To explore the changes of brain energy metabolism following acrylamide (ACR) poisoning. METHODS: Creatie kinase (CK), adenosine triphosphate (ATP), adenosine diphosphate(ADP), adenosine 5'-monophosphate(AMP) and glucose contents in brain were observed in O1a mice and 6J mice following ACR intoxication by enzyme analytical method. RESULTS: ATP, CK and glucose levels decreased transiently in O1a mice, while ATP level in 6J mice was significantly decreased (1.76 mumol/g, P < 0.01), as compared to the control (2.53 mumol/g) but ADP and AMP were increased, glucose was decreased. The activity of CK in poisoned group (1.13 mumol/g, P < 0.01) was lower than that of control (3.16 mumol/g and lasted for 5 weeks). CONCLUSION: The influence of ACR on O1a mice was slight and reversible but on 6J mice was severe and lasting. There was severe damage to the potential energy supply compensation, which might be the biochemical basis of neuron damage induced by acrylamide.

[Effect of acrylamide on creatine kinase and adenosine triphosphate in brain of mice and its significance] Publishing Authors By Initials

Q He,M Han,M Rao,

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[Effect of acrylamide on creatine kinase and adenosine triphosphate in brain of mice and its significance] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Z

VOLUME: 20

Page Numbers: 195-6

Journal Abbreviation: Zhonghua Lao Dong Wei Sheng Zh

ISSN: 1001-9391

DAY: 25

MONTH: Jun

YEAR: 2002

[Effect of acrylamide on creatine kinase and adenosine triphosphate in brain of mice and its significance] Information

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LANGUAGE: chi

NlmUniqueID: 8410840

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AFFILIATION: Department of Neurology, Shenzhen Red Cross Hospital, Shenzhen 518035, China.

Country: China

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MEDLINETA: Zhonghua Lao Dong Wei Sheng Zh

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