[Effect of a proteinase-activated receptor-2 (PAR-2) agonist on tryptase release from human mast cells]

[Effect of a proteinase-activated receptor-2 (PAR-2) agonist on tryptase release from human mast cells] Research Abstract Details 

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[Effect of a proteinase-activated receptor-2 (PAR-2) agonist on tryptase release from human mast cells] Abstract Text:

Shao-Heng He,Hua Xie,Yong-Song He,

Proteinase-activated receptor-2 (PAR-2) expression has been observed on numerous cell types. However, little is known about the functional expression of PAR-2 in human mast cells. In the current study, the actions of a PAR-2 agonist trans-cinnamoyl-Leu-Ile-Gly-Arg-Leu-Orn-amide (tc-LIGRLO) on tryptase release from dispersed human colonic mast cells were examined. The results showed that tc-LIGRLO was able to induce a fold increase in tryptase release over the basal level following a 15 min incubation of colonic mast cells, whereas tc-OLRGIL did not have any effect on tryptase release. The potency of tc-LIGRLO appeared greater than that of anti-IgE and calcium ionophore A23187 (CI) in induction of tryptase release. Extending the incubation time to 30 min had no significant effect on the actions of tc-LIGRLO or anti-IgE. In the time course study, it was observed that the tryptase release from mast cells induced by tc-LIGRLO started at 1 min and peaked at 3 min following incubation. The above-mentioned results indicate that tc-LIGRLO is a potent stimulus of tryptase release from human mast cells, which strongly suggests that PAR-2s are expressed in human mast cells.

[Effect of a proteinase-activated receptor-2 (PAR-2) agonist on tryptase release from human mast cells] Publishing Authors By Initials

SH He,H Xie,YS He,

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[Effect of a proteinase-activated receptor-2 (PAR-2) agonist on tryptase release from human mast cells] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Sheng li xue bao : [Acta physiologica Sinica]

VOLUME: 54

Page Numbers: 531-4

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ISSN: 0371-0874

DAY: 25

MONTH: Dec

YEAR: 2002

[Effect of a proteinase-activated receptor-2 (PAR-2) agonist on tryptase release from human mast cells] Information

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LANGUAGE: chi

NlmUniqueID: 20730130

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AFFILIATION: Allergy and Inflammation Research Institute, the Medical College of Shantou University, Shantou 515031. shaohenghe@hotmail.com

Country: China

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MEDLINETA: Sheng Li Xue Bao

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