Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women.

Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women. Abstract Text:

Eduardo E Castrillon,Brian E Cairns,Malin Ernberg,Kelun Wang,Barry J Sessle,Lars Arendt-Nielsen,Peter Svensson,

AIMS: To test the hypothesis that local injection of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine would significantly attenuate glutamate-evoked masseter mechanical sensitization and muscle pain in healthy young women either taking oral contraceptives (W+OC) or not taking oral contraceptives (W-OC). METHODS: Experimental pain was evoked in 47 healthy female subjects (W+OC, n=25; W-OC, n=22) by 2 injections of glutamate (0.2 mL, 1 mol/L) into the masseter muscle. A first injection of glutamate alone was followed by a second injection, 35 minutes later, of glutamate combined with ketamine (0, 1, or 10 mmol/L). Evoked pain intensity was scored on a 10-cm electronic visual analog scale (VAS). Distribution of perceived pain was drawn on a lateral view of the face (pain drawing). Masseter muscle pressure pain thresholds (PPT) and pressure-pain tolerances (PPTOL) were determined bilaterally before and at regular time intervals after injections. Analyses of variance (ANOVA) were used to test the data. RESULTS: There were no main effects of ketamine on any of the VAS pain parameters or on the pain drawing (ANOVAs: P > .055). Furthermore, there were no differences in PPT, PPTOL, VAS peak pain, duration, overall VAS pain, or pain drawing when W-OC were compared with W+OC (ANOVAs: P > .087). Repeated injection of glutamate alone significantly decreased PPT and PPTOL (ANOVAs: P < .001); however, this effect was not significantly attenuated by ketamine. CONCLUSIONS: Peripherally administered ketamine had no effect on glutamate-evoked masseter muscle pain and sensitization in healthy young women, which contrasts with recent observations in healthy young men. Further studies will be needed to reveal the mechanisms that underlie this apparent sex-related difference in ketamine-mediated analgesia.

Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women. Publishing Authors By Initials

EE Castrillon,BE Cairns,M Ernberg,K Wang,BJ Sessle,L Arendt-Nielsen,P Svensson,

For similar proteins: membrane proteins: receptors, cell surface: receptors, neurotransmitter: receptors, amino acid: receptors, glutamate: receptors, n-methyl-d-aspartate research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, neurotransmitter: receptors, amino acid: receptors, glutamate: receptors, n-methyl-d-aspartate research

PUBMED ID PMID:

MEDLINE DATE:

Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of orofacial pain

VOLUME: 21

Page Numbers: 216-24

Journal Abbreviation:

ISSN: 1064-6655

DAY: 26

MONTH: 11

YEAR: 2007

Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9418507

Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women. Keywords Mesh Terms:

KEYWORDS: Receptors, N-Methyl-D-Aspartate

MESH TERMS: antagonists & inhibitors

Chemical & Substance for Abstract: Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women. Information

Substance Name: Ketamine

Registry Number: 6740-88-1

Grant and Affiliation Information for Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women.

AFFILIATION: Department of Clinical Oral Physiology, School of Dentistry, University of Aarhus, Aarhus, Denmark. ecastrillon@odont.au.dk

Country: United States

AGENCY: United States NIDCR

GRANT: DE 15420

ACRONYM: DE

MEDLINETA: J Orofac Pain

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women Related Publications

• Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity.
• Acute aortic syndromes: time to talk of many things.
• An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif.
• Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia.
• Central sensitization phenomena after third molar surgery: A quantitative sensory testing study.
• Denatured hemoproteins as catalysts in lipid oxidation.
• Determination of dextromethorphan and its metabolites in plasma by dual column liquid chromatography and fluorimetric detection.
• Dispatcher-assisted telephone-guided cardiopulmonary resuscitation: an underused lifesaving system.
• Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes.
• Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women.
• Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes.
• Effect of conditioning electrical stimuli on temporalis electromyographic activity during sleep.
• Effects of local anesthetics on somatosensory function in the temporomandibular joint area.
• Efficacy and safety of anticoagulant prophylaxis to prevent venous thromboembolism in acutely ill medical inpatients: a meta-analysis.
• FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart.
• Formation and uptake of arylhydroxylamine-haptenated proteins in human dendritic cells.
• General intellectual capacity of young men with cleft lip with or without cleft palate and cleft palate alone.
• Human papillomavirus (HPV), DNA aberrations and cell cycle progression in anal squamous cell carcinoma patients.
• Hypersensitivity to Mechanical and Intra-articular Electrical Stimuli in Persons with Painful Temporomandibular Joints.
• Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals.
• Spatio-temporal changes in germination and radical elongation of barley seeds tracked by proteome analysis of dissected embryo, aleurone layer, and endosperm tissues.
• Speech results in adult Swedish patients born with unilateral complete cleft lip and palate.
• Survival is similar after standard treatment and chest compression only in out-of-hospital bystander cardiopulmonary resuscitation.
• The 'pair of sugar tongs' site on the non-catalytic domain C of barley alpha-amylase participates in substrate binding and activity.
• The Second JOR Summer School Review Series.
• The impact of pain and depression on assessment of rehabilitation need: a cross-sectional study in long-term sick-listed patients.
• Vagal influences on gastric acid secretion. Experimental studies in cats.
• Vertical structure of recent Arctic warming.
• [In Process Citation]
• [Not Available.]