Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial.

Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial. Abstract Text:

Kristin L Campbell,Anne McTiernan,Shuying S Li,Bess E Sorensen,Yutaka Yasui,Johanna W Lampe,Irena B King,Cornelia M Ulrich,Rebecca E Rudolph,Melinda L Irwin,Christina Surawicz,Kamran Ayub,John D Potter,Paul D Lampe,Kristin L Campbell,Anne McTiernan,Shuying S Li,Bess E Sorensen,Yutaka Yasui,Johanna W Lampe,Irena B King,Cornelia M Ulrich,Rebecca E Rudolph,Melinda L Irwin,Christina Surawicz,Kamran Ayub,John D Potter,Paul D Lampe,

BACKGROUND: Cellular proliferation and apoptosis (cell death) are highly regulated in the colon as insufficient apoptosis may lead to polyps and cancer. Physical activity decreases risk of colon cancer in observational studies, but the biological basis is not well defined. The objective of this study is to examine the effects of a 12-month aerobic exercise program on expression of proteins that promote (Bax) or inhibit (Bcl-2) apoptosis in colon crypts. METHODS: Two hundred two sedentary participants, 40 to 75 years, were randomly assigned to moderate-to-vigorous intensity exercise for 60 min per day, 6 days per week for 12 months, or usual lifestyle. Colon crypt samples were obtained at baseline and 12 months. Bcl-2 and Bax expression was measured by immunohistochemistry. RESULTS: Bax density at the bottom of crypts increased in male exercisers versus controls (+0.87 versus -0.18; P = 0.05), whereas the ratio of Bcl-2 to Bax at the bottom and middle of crypts decreased as aerobic fitness (VO(2)max) increased (P trend = 0.02 and 0.05, respectively). In female exercisers, Bax density in the middle of crypts decreased (-0.36 versus +0.69; P = 0.03) and Bcl-2 to Bax ratio at the top of crypts increased versus controls (+0.46 versus -0.85; P = 0.03). Bax density in the middle of crypts also decreased as minutes per week of exercise increased (P trend = 0.03). CONCLUSIONS: A 12-month exercise intervention resulted in greater expression of proteins that promote apoptosis at the bottom of colon crypts in men and decreased expression of proteins that promote apoptosis at the middle and top of colon crypts in women. The difference in effect by gender and location of observed changes warrants further study.

Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial. Publishing Authors By Initials

KL Campbell,A McTiernan,SS Li,BE Sorensen,Y Yasui,JW Lampe,IB King,CM Ulrich,RE Rudolph,ML Irwin,C Surawicz,K Ayub,JD Potter,PD Lampe,KL Campbell,A McTiernan,SS Li,BE Sorensen,Y Yasui,JW Lampe,IB King,CM Ulrich,RE Rudolph,ML Irwin,C Surawicz,K Ayub,JD Potter,PD Lampe,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 1767-74

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 14

MONTH: Sep

YEAR: 2007

Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9200608

Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial.

AFFILIATION: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4-B402, Seattle, WA 98109-1024, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA 77572-01

ACRONYM: CA

MEDLINETA: Cancer Epidemiol Biomarkers Pr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial Related Publications

• A pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women.
• An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels.
• Blood loss and blood transfusion.
• Changing concepts in the treatment of urinary infections.
• Demographic, anthropometric, and lifestyle factors and dietary intakes in relation to daidzein-metabolizing phenotypes among premenopausal women in the United States.
• Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial.
• Identification of hepatitis C virus subtype 2c by sequencing analysis in patients from Córdoba, Argentina.
• Key connexin 43 phosphorylation events regulate the gap junction life cycle.
• Long-range evaluation of radiotherapy in rheumatoid spondylitis.
• Long-term follow-up after abdominal pregnancy.
• Optimization of terminal restriction fragment polymorphism (TRFLP) analysis of human gut microbiota.
• Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC.
• Phytochemical Regulation of UDP-Glucuronosyltransferases: Implications for Cancer Prevention.
• Radiation tolerance of the central nervous system.
• Simulated fate and transport of metolachlor in the unsaturated zone, Maryland, USA.
• The C-terminus of connexin43 adopts different conformations in the Golgi and gap junction as detected with structure-specific antibodies.
• The benefits of using Guyton's model in a hypotensive control system.
• The direct radiolysis and the radiation-sensitized hydrogenation of ethylene.
• UGT1A1 polymorphism is associated with serum bilirubin concentrations in a randomized, controlled, fruit and vegetable feeding trial.
• UGT1A6 polymorphism and salicylic acid glucuronidation following aspirin.
• [Decline, low incidence and disappearance of leprosy in the Caribbean Archipelago and Central America; preliminary note.]
• [Different labour behaviours following induction, using oxytocin and prostaglandin F2 alpha (Enzaprost) (author's transl)]
• [Munro's microabscess--before Munro]
• [Plastic correction of thoracic wall burns with reference to the female breast]
• [Prevalence of abnormalities in the clinical records of our hospital for a period of 27 years.]
• [Prevention of Rho(D) sensitization using anti D gammaglobulin produced in Hungary]
• [Prevention of respiratory distress syndrome prior to delivery using steroids]
• [Sexual development: development of secondary sex characteristics--Tanner stages 25 years later]
• [Significance and possibilities of early diagnosis of twin pregnancy]
• [Upper urinary tract changes in carcinoma of the cervix]