Effect of 6-OHDA lesions of the dopaminergic mesolimbic system on drug priming induced reinstatement of extinguished morphine CPP in rats.

Effect of 6-OHDA lesions of the dopaminergic mesolimbic system on drug priming induced reinstatement of extinguished morphine CPP in rats. Research Abstract Details 

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Effect of 6-OHDA lesions of the dopaminergic mesolimbic system on drug priming induced reinstatement of extinguished morphine CPP in rats. Abstract Text:

Bin Wang,Fei Luo,Xuecai Ge,Aihua Fu,Jisheng Han,

OBJECTIVE: To evaluate the role played by mesolimbic dopaminergic system in the reinstatement of drug-seeking behavior induced by priming injections of morphine. METHODS: After the extinguishment of morphine conditioned place preference (CPP), low-dose catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) was bilaterally injected into ventral tegmental area (VTA, 1 g.L-1) and nucleus accumbens (NAc, 5 g.L-1) before being primed with low-dose morphine. RESULTS: The effects of drug-priming to induce reinstatement of morphine CPP could be completely abolished by 6-OHDA microinjected into VTA to damage the perikaryon of dopaminergic neurons, or into NAc to lesion the terminal field of the dopaminergic pathway. CONCLUSION: The functional integrality of the mesolimbic dopaminergic system is indispensable for drug priming-induced reinstatement of conditioned place preference.

Effect of 6-OHDA lesions of the dopaminergic mesolimbic system on drug priming induced reinstatement of extinguished morphine CPP in rats. Publishing Authors By Initials

B Wang,F Luo,X Ge,A Fu,J Han,

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Effect of 6-OHDA lesions of the dopaminergic mesolimbic system on drug priming induced reinstatement of extinguished morphine CPP in rats. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Pe

VOLUME: 35

Page Numbers: 449-52

Journal Abbreviation: Beijing Da Xue Xue Bao

ISSN: 1671-167X

DAY: 6

MONTH: Oct

YEAR: 2003

Effect of 6-OHDA lesions of the dopaminergic mesolimbic system on drug priming induced reinstatement of extinguished morphine CPP in rats. Information

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LANGUAGE: eng

NlmUniqueID: 101125284

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Grant and Affiliation Information for Effect of 6-OHDA lesions of the dopaminergic mesolimbic system on drug priming induced reinstatement of extinguished morphine CPP in rats.

AFFILIATION: Neuroscience Research Institute, Department of Neurobiology, Peking University, Beijing 100083, China.

Country: China

AGENCY: United States NIDA

GRANT: DA 03983

ACRONYM: DA

MEDLINETA: Beijing Da Xue Xue Bao

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