Eczema, atopy and allergen exposure in adults: a population-based study.

Eczema, atopy and allergen exposure in adults: a population-based study. Research Abstract Details 

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Eczema, atopy and allergen exposure in adults: a population-based study. Abstract Text:

J Harrop,S Chinn,G Verlato,M Olivieri,D ,M Wjst,C Janson,J-P Zock,B Leynaert,D Gislason,M Ponzio,S Villani,A Carosso,C Svanes,J Heinrich,D Jarvis,

BACKGROUND: There are few published studies on geographical variation in prevalence of eczema in adults or its association with recognised risk factors for allergic disease. OBJECTIVE: To describe the geographical variation in prevalence of eczema in adults, assess the associations with sociodemographic risk factors, serum-specific IgE and IgG, and exposure to allergen. METHODS: A community-based sample of 8206 adults aged 27-56 years, in 25 European centres and Portland, USA, provided questionnaire information on symptoms of eczema. Serum-specific IgE to house dust mite (HDM), cat, grass and Cladosporium, and IgG and IgG4 to HDM and cat were measured. Mattress levels of mite and cat allergen were assessed. RESULTS: Overall prevalence of eczema was 7.1% (range between countries of 2.2-17.6%). Eczema was associated with female gender [odds ratio (OR) 1.25; 95% confidence interval (CI) (1.01-1.55)], family history of atopic disease (OR 1.43; 95% CI 1.18-1.74), IgE sensitization to at least one allergen (OR 1.50; 95% CI 1.19-1.90), particularly Cladosporium (OR 3.65; 95% CI 1.81-7.37), and total IgE. Eczema was negatively associated with age and no clear associations were observed with sibship size, mattress mite and cat allergen levels or with cat and HDM-specific IgG or IgG4. CONCLUSIONS: There is geographical variation in the prevalence of eczema in adults both within and between countries. Although the disease is associated with IgE sensitization, in this study it was not related to mattress mite or cat allergen levels.

Eczema, atopy and allergen exposure in adults: a population-based study. Publishing Authors By Initials

J Harrop,S Chinn,G Verlato,M Olivieri,D ,M Wjst,C Janson,JP Zock,B Leynaert,D Gislason,M Ponzio,S Villani,A Carosso,C Svanes,J Heinrich,D Jarvis,

For similar investigative techniques: epidemiologic methods: data collection: vital statistics: morbidity: prevalence research abstracts see: investigative techniques: epidemiologic methods: data collection: vital statistics: morbidity: prevalence research

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Eczema, atopy and allergen exposure in adults: a population-based study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical and experimental allergy : journal of the

VOLUME: 37

Page Numbers: 526-35

Journal Abbreviation:

ISSN: 0954-7894

DAY: 3

MONTH: Apr

YEAR: 2007

Eczema, atopy and allergen exposure in adults: a population-based study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8906443

Eczema, atopy and allergen exposure in adults: a population-based study. Keywords Mesh Terms:

KEYWORDS: Prevalence

MESH TERMS: blood

Chemical & Substance for Abstract: Eczema, atopy and allergen exposure in adults: a population-based study. Information

Substance Name: Dermatophagoides pteronyssinus antigen p

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Eczema, atopy and allergen exposure in adults: a population-based study.

AFFILIATION: School of Medicine, King's College London, London UK, and Department of Allergy, Respiratory Medicine and Sleep, University Hospital (E7), Reykjavik, Iceland.

Country: England

AGENCY: United States NHLBI

GRANT: R01 HL62633-01

ACRONYM: HL

MEDLINETA: Clin Exp Allergy

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