Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family.

Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. Research Abstract Details 

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Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. Abstract Text:

N M Wolfman,G Hattersley,K Cox,A J Celeste,R Nelson,N Yamaji,J L Dube,E DiBlasio-Smith,J Nove,J J Song,J M Wozney,V Rosen,

Little is known about the regulatory signals involved in tendon and ligament formation, and this lack of understanding has hindered attempts to develop biologically based therapies for tendon and ligament repair. Here we report that growth and differentiation factors (GDFs) 5, 6, and 7, members of the TGF-beta gene superfamily that are most related to the bone morphogenetic proteins, induce neotendon/ligament formation when implanted at ectopic sites in vivo. Analysis of tissue induced by GDF-5, 6, or 7, containing implants by currently available morphological and molecular criteria used to characterize tendon and ligament, adds further evidence to the idea that these GDFs act as signaling molecules during embryonic tendon/ligament formation. In addition, comparative in situ localizations of the GDF-5, 6, and 7 mRNAs suggest that these molecules are important regulatory components of synovial joint morphogenesis.

Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. Publishing Authors By Initials

NM Wolfman,G Hattersley,K Cox,AJ Celeste,R Nelson,N Yamaji,JL Dube,E DiBlasio-Smith,J Nove,JJ Song,JM Wozney,V Rosen,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of clinical investigation

VOLUME: 100

Page Numbers: 321-30

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 15

MONTH: Jul

YEAR: 1997

Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. Information

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LANGUAGE: eng

NlmUniqueID: 7802877

Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. Information

Substance Name: Elastin

Registry Number: 9007-58-3

Grant and Affiliation Information for Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family.

AFFILIATION: Genetics Institute, Inc., Cambridge, Massachusetts 02140, USA.

Country: UNITED STATES

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MEDLINETA: J Clin Invest

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