Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds.

Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. Research Abstract Details 

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Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. Abstract Text:

K Whang,D C Tsai,E K Nam,M Aitken,S M Sprague,P K Patel,K E Healy,

Drug delivery devices have received considerable interest in the field of tissue engineering due to the advent of proteins that can induce proliferation and differentiation of various cells to form specific tissues and organs, for example, bone morphogenetic protein (BMP-2) for osteogenesis. In this work the delivery of a clinically relevant bioactive factor, recombinant human rhBMP-2, was tested in vivo in a rat ectopic bone induction assay. Contact radiography and radiomorphometry showed significantly more radiopacity (1798+/-183 mm2 versus. 784+/-570 mm2 radiopaque area/g scaffold) in the BMP scaffolds than controls (p < 0.002). De novo woven bone and abundant osteoid formation were confirmed from histological sections while controls contained minimal amounts of tissue. Histomorphometry revealed significantly more bone (124+/-93 mm2 versus 7+/-12 mm2) and osteoid (72+/-43 mm2 versus 20+/-21 mm2) in the BMP implants (p < 0.001). These scaffolds demonstrated the ability to deliver viable rhBMP-2 and to induce bone formation in an ectopic site.

Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. Publishing Authors By Initials

K Whang,DC Tsai,EK Nam,M Aitken,SM Sprague,PK Patel,KE Healy,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomedical materials research

VOLUME: 42

Page Numbers: 491-9

Journal Abbreviation: J. Biomed. Mater. Res.

ISSN: 0021-9304

DAY: 15

MONTH: Dec

YEAR: 1998

Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. Information

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LANGUAGE: eng

NlmUniqueID: 112726

Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. Information

Substance Name: recombinant human bone morphogenetic pro

Registry Number: 0

Grant and Affiliation Information for Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds.

AFFILIATION: Division of Biological Materials, Northwestern University Dental School, Chicago, Illinois 60611-3008, USA.

Country: UNITED STATES

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MEDLINETA: J Biomed Mater Res

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