Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein.

Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein. Research Abstract Details 

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Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein. Abstract Text:

M Yamamoto,Y Tabata,Y Ikada,M Yamamoto,Y Tabata,Y Ikada,

Biodegradable hydrogels were prepared from gelatin by glutaraldehyde cross-linking for release matrix of recombinant human bone morphogenetic protein-2 (BMP-2). BMP-2 solution was impregnated into the dried hydrogels to prepare BMP-2-incorporating gelatin hydrogels. In the in vitro study, enhanced retention of BMP-2 was observed from the BMP-2-incorporating gelatin hydrogels after an initial burst of BMP-2 incorporated initially in the hydrogel. Following subcutaneous implantation of (125)I-labeled BMP-2-incorporating gelatin hydrogels in the back of mice, the radioactivity remaining in the hydrogels was measured to estimate the in vivo release profile of BMP-2. It was found that BMP-2 was retained in the hydrogels for longer than 30 days, whereas 99% of BMP-2 injected in the solution form was cleared from the injected site within one day, completely disappearing within 3 days. Ectopic bone formation studies demonstrated that BMP-2-incorporating gelatin hydrogels exhibited a more potent ability for bone induction than solution injection of BMP-2. This finding indicates that enhanced retention of BMP-2 is promotes its ability to induce ectopic bone formation.

Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein. Publishing Authors By Initials

M Yamamoto,Y Tabata,Y Ikada,M Yamamoto,Y Tabata,Y Ikada,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 9

Page Numbers: 439-58

Journal Abbreviation:

ISSN: 0920-5063

DAY: 19

MONTH: 11

YEAR: 1998

Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein. Information

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LANGUAGE: eng

NlmUniqueID: 9007393

Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein. Information

Substance Name: Gelatin

Registry Number: 9000-70-8

Grant and Affiliation Information for Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein.

AFFILIATION: Research Center for Biomedical Engineering, Kyoto University, Japan.

Country: NETHERLANDS

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MEDLINETA: J Biomater Sci Polym Ed

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