Ebp1 association with nucleophosmin/b23 is essential for regulating cell proliferation and suppressing apoptosis.

Ebp1 association with nucleophosmin/b23 is essential for regulating cell proliferation and suppressing apoptosis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Ebp1 association with nucleophosmin/b23 is essential for regulating cell proliferation and suppressing apoptosis. Abstract Text:

Masashi Okada,Sung-Wuk Jang,Keqiang Ye,Masashi Okada,Sung-Wuk Jang,Keqiang Ye,Masashi Okada,Sung-Wuk Jang,Keqiang Ye,

Ebp1 and NPM/B23 are essential for cell proliferation and survival. Ebp1 possesses p42 and p48 isoforms. Whereas p42 exclusively resides in the cytoplasm, p48 localizes in both the cytoplasm and the nucleolus. Here, we show that Ebp1 forms a complex with B23, and this complex plays a critical role in cell proliferation and survival. p42 specifically associates with B23 upon epidermal growth factor stimulation, while p48 constantly binds B23. Moreover, Ser(360) phosphorylation in p42, but not p48, is critical for the interaction. p48 constitutively binds B23 in the nucleolus, for which B23 Lys(263) sumoylation is indispensable. By contrast, p42 selectively binds unsumoylated B23 mutants. Interestingly, B23 K263R, an unsumoylated mutant, triggers p42 nuclear translocation and interacts with it in the nucleus even in the absence of epidermal growth factor. In contrast, the nucleolar residency of p48 is abolished in B23 K263R cells. During the cell cycle, p42 selectively colocalizes with B23 in the mitotic cells, correlating with its phosphorylation status in mitosis. Knocking down of B23 or Ebp1 substantially decreases ribosome biogenesis and cell survival. Thus, B23 distinctively binds Ebp1 isoforms and regulates cell proliferation and survival through p42 and p48, respectively.

Ebp1 association with nucleophosmin/b23 is essential for regulating cell proliferation and suppressing apoptosis. Publishing Authors By Initials

M Okada,SW Jang,K Ye,M Okada,SW Jang,K Ye,M Okada,SW Jang,K Ye,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Ebp1 association with nucleophosmin/b23 is essential for regulating cell proliferation and suppressing apoptosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 36744-54

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 18

MONTH: 10

YEAR: 2007

Ebp1 association with nucleophosmin/b23 is essential for regulating cell proliferation and suppressing apoptosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

Ebp1 association with nucleophosmin/b23 is essential for regulating cell proliferation and suppressing apoptosis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Ebp1 association with nucleophosmin/b23 is essential for regulating cell proliferation and suppressing apoptosis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Ebp1 association with nucleophosmin/b23 is essential for regulating cell proliferation and suppressing apoptosis.

AFFILIATION: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biol Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Ebp1 association with nucleophosmin/b23 is essential for regulating cell proliferation and suppressing apoptosis Related Publications

• Artificial gene networks for objective comparison of analysis algorithms.
• Cloning, expression, and mapping of GDP-D-mannose pyrophosphorylase cDNA from tomato (Lycopersicon esculentum).
• Dietary patterns and risk of squamous-cell carcinoma and adenocarcinoma of the esophagus and adenocarcinoma of the gastric cardia: a population-based case-control study in Sweden.
• Relationship of intracellular free Ca2+ concentration and calcium-activated chloride channels of pulmonary artery smooth muscle cells in rats under hypoxic conditions.
• The beneficial effects of high-density lipoprotein on adipocytes may relate to its anti-atherogenic properties.
• [A death due to misdiagnosis of cerebral falciparum malaria]
• [Application of mycophenolate mofetil in hepatitis C patients after kidney transplantation]
• [Construction of VEGF eukaryotic expression vector and its expression in endothelial cells and cardiac myocytes in-vitro]
• [Determination of urinary trans, trans-muconic acid by high performance liquid chromatography]
• [Disequilibrium linkage between the polymorphism in exons 2, 3 and 4 of the MICA gene and HLA-B antigen of patient with ankylosing spondylitis]
• [Effect of high level spinal cord injury on rat heart function.]
• [Effects of vascular endothelial growth factor on differentiation and function of dendritic cells generated from CD34+ hematopoietic progenitor cells in vitro.]
• [Endovascular stent-graft exclusion for Stanford B type aortic dissections: a report of 146 patients]
• [Expression of bcl-2, c-erbB2, and p53 protein in cervical epithelial carcinogenesis]
• [HLA-DM gene polymorphism in Cantonese with condyloma acuminata]
• [Identification and characterization of LAPTM4B encoded by a human hepatocellular carcinoma-associated novel gene]
• [Non-surgical therapy for hepatocellular carcinoma]
• [Nondestructive analysis of protein and fat in whole-kernel soybean by NIR]
• [Relationship between the genetic background of donor KIR recipient HLA and the outcomes in HLA-identical sibling HSCT]
• [Response rate of AML-XH-99 protocol in the treatment of 82 childhood acute myeloid leukemia]
• [Surgery strategy on obstructive sleep apnea hypopnea syndrome]
• [Synthesis, characterization and luminescence properties of coordination compounds of rare earth with p-tert-butyl-calix[8] arene]
• [Synthesis, characterization and relaxivity of dimeric DTPA-gadonium (III) complexes with long chain alkyl esters of L-lysine]
• [Textual research on Lu You's poet on diseases during his trip to Nanchang]
• [Texture features' extraction of B-scan schistosomial fibrosis images using the Peleg method]
• [The design and realization of Web-view PACS browser]
• [The influence of abscisic acid treatment on desiccation tolerance in Dendrobium candidum protocorm-like bodies]
• [Transcatheter closure of ruptured sinus of valsalva aneurysm using Amplatzer duct occluder]
• [Value of serum-vascular endothelial growth factor in the differential diagnosis of solitary pulmonary nodule]
• [Vitamin C reverses benzo (a) pyrene-induced cell cycle changes by E2F pathway]