Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection.

Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection. Research Abstract Details 

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Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection. Abstract Text:

Nicolas P Andrews,Christopher D Pack,Vaiva Vezys,Glen N Barber,Aron E Lukacher,

Chronic Ag exposure during persistent viral infection erodes virus-specific CD8 T cell numbers and effector function, with a concomitant loss of pathogen control. Less clear are the respective contributions of Ag-specific and Ag-nonspecific (bystander) events on the quantity, quality, and maintenance of antiviral CD8 T cells responding to persistent virus infection. In this study, we show that low-dose inoculation with mouse polyomavirus (PyV) elicits a delayed, but numerically equivalent, antiviral CD8 T cell response compared with high-dose inoculation. Low-dose infection generated virus-specific CD8 T cells endowed with multicytokine functionality and a superior per cell capacity to produce IFN-gamma. PyV-specific CD8 T cells primed by low-dose inoculation also expressed higher levels of IL-7Ralpha and bcl-2 and possessed enhanced Ag-independent survival. Importantly, the quantity and quality of the antiviral CD8 T cell response elicited by dendritic cell-mediated immunization were mitigated by infection with a mutant PyV lacking the dominant CD8 T cell viral epitope. These findings suggest that the fitness of the CD8 T cell response to persistent virus infection is programmed in large part by early virus-associated Ag-nonspecific factors, and imply that limiting bystander inflammation at the time of inoculation, independent of Ag load, may optimize adaptive immunity to persistent viral infection.

Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection. Publishing Authors By Initials

NP Andrews,CD Pack,V Vezys,GN Barber,AE Lukacher,

For similar virus diseases: tumor virus infections research abstracts see: virus diseases: tumor virus infections research

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Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 178

Page Numbers: 7267-75

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Jun

YEAR: 2007

Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection. Keywords Mesh Terms:

KEYWORDS: Tumor Virus Infections

MESH TERMS: prevention & control

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Grant and Affiliation Information for Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection.

AFFILIATION: Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01CA71971

ACRONYM: CA

MEDLINETA: J Immunol

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