Early rheumatoid arthritis in a patient with Sjögren's syndrome and pulmonary nodular amyloidosis: clinical implication of early limited use of infliximab.

Early rheumatoid arthritis in a patient with Sjögren's syndrome and pulmonary nodular amyloidosis: clinical implication of early limited use of infliximab. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Early rheumatoid arthritis in a patient with Sjögren's syndrome and pulmonary nodular amyloidosis: clinical implication of early limited use of infliximab. Abstract Text:

Shunsuke Mori,Yukinori Koga,Fumiya Imamura,Isamu Cho,Mineharu Sugimoto,Shunsuke Mori,Yukinori Koga,Fumiya Imamura,Isamu Cho,Mineharu Sugimoto,Shunsuke Mori,Yukinori Koga,Fumiya Imamura,Isamu Cho,Mineharu Sugimoto,

Infliximab, an anti-tumor necrosis factor alpha antibody, is among the most effective therapies for rheumatoid arthritis (RA). In this study, we report a patient with early RA of 6 months who has Sjögren's syndrome and pulmonary nodular lesions concomitantly. The patient did not respond to methotrexate (MTX, 6;Smg per week) for 3 months. When introduction of infliximab therapy is considered, we need to exclude the possibility of pulmonary granulomatous infection and malignancy. With the use of computed tomography-guided percutaneous needle biopsy and subsequent histological examinations, this case was rapidly and confidently diagnosed as localized pulmonary nodular amyloidosis. Immunochemical staining showed light chain type nodular amyloidosis by a deposition of immunoglobulin kappa light chains, which is a rare condition in a patient with Sjögren's syndrome. We started combination therapy of infliximab (200;Smg per infusion) and MTX (6;Smg per week). Because of severe systemic eruption, this therapy was stopped halfway through the third infusion of infliximab, and MTX monotherapy was continued. Despite the withdrawal of infliximab therapy, the C-reactive protein values were decreased to an undetectable level at week 14, and the disease activity score for 28 joints was 3.1 at week 22. Clinical remission has been maintained more than 14 months with MTX alone. Infliximab has been used only for patients with recalcitrant RA, because the cost of its lifelong use would be an economic burden in most cases. An optimal and affordable strategy for the treatment of early RA should be developed. Our findings may support the idea that the combination therapy of infliximab and MTX for early RA alters the course of the disease.

Early rheumatoid arthritis in a patient with Sjögren's syndrome and pulmonary nodular amyloidosis: clinical implication of early limited use of infliximab. Publishing Authors By Initials

S Mori,Y Koga,F Imamura,I Cho,M Sugimoto,S Mori,Y Koga,F Imamura,I Cho,M Sugimoto,S Mori,Y Koga,F Imamura,I Cho,M Sugimoto,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Early rheumatoid arthritis in a patient with Sjögren's syndrome and pulmonary nodular amyloidosis: clinical implication of early limited use of infliximab. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Modern rheumatology / the Japan Rheumatism Associa

VOLUME: 17

Page Numbers: 500-6

Journal Abbreviation: Mod Rheumatol

ISSN: 1439-7595

DAY: 20

MONTH: 12

YEAR: 2007

Early rheumatoid arthritis in a patient with Sjögren's syndrome and pulmonary nodular amyloidosis: clinical implication of early limited use of infliximab. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100959226

Early rheumatoid arthritis in a patient with Sjögren's syndrome and pulmonary nodular amyloidosis: clinical implication of early limited use of infliximab. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Early rheumatoid arthritis in a patient with Sjögren's syndrome and pulmonary nodular amyloidosis: clinical implication of early limited use of infliximab. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Early rheumatoid arthritis in a patient with Sjögren's syndrome and pulmonary nodular amyloidosis: clinical implication of early limited use of infliximab.

AFFILIATION: Clinical Research Center for Rheumatic Disease and Department of Rheumatology, Kumamoto Saishunsou National Hospital, 2659 Suya, Kohshi, Kumamoto, 861-1196, Japan, moris@saisyunsou1.hosp.go.jp.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mod Rheumatol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Early rheumatoid arthritis in a patient with Sjögren's syndrome and pulmonary nodular amyloidosis: clinical implication of early limited use of infliximab Related Publications

• A multi-fluorescent MDA435 cell line for mitosis inhibitor studies: simultaneous visualization of chromatin, microtubules, and nuclear envelope in living cells.
• A novel vacuolar myopathy with dilated cardiomyopathy.
• Altered prephenate dehydratase in phenylalanine-excreting mutants of Brevibacterium flavum.
• Altered regulatory mechanisms for tryptophan synthesis in fluorotryptophan-resistant mutants of Brevibacterium flavum.
• Complete deficiency of 5'-nucleotidase activity in Escherichia coli leads to loss of growth on purine nucleotides but not of their excretion.
• Conformational switch of a functional nanowire based on the DNA G-quadruplex.
• Dynamic behavior of FCHO1 revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation.
• Dynamic properties of human eyes.
• Early rheumatoid arthritis in a patient with Sjögren's syndrome and pulmonary nodular amyloidosis: clinical implication of early limited use of infliximab.
• Effect of enzyme concentration on regulation of dissociable chorismate mutase in Brevibacterium flavum.
• Effects of cosolutes on the thermodynamic stability of parallel DNA duplex and triplex.
• Estimation of the in vivo translational activity of rat liver mitochondria without use of an antibiotic.
• Functionalization of DNA by the base pair-mimic nucleosides.
• Hydration regulates the thermodynamic stability of DNA structures under molecular crowding conditions.
• MPO-ANCA-positive IgA nephropathy successfully treated with tonsillectomy.
• Mitochondrial and cytosolic localization of a single glycerate kinase in rat kidney cortex.
• Purification of rat liver glycerate kinase and studies of its enzymatic and immunological properties.
• Retroviral integration site analysis and the fate of transduced clones in an MDR1 gene therapy protocol targeting metastatic breast cancer.
• Role of glucagon in increase of hepatic glycerate kinase of adult and neonatal rats.
• Serum insulin-like growth factor-I level is associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes mellitus.
• Synthesis and pharmacological profile of serofendic acids A and B.
• The Combination of High Glucose and Advanced Glycation End-products (AGEs) Inhibits the Mineralization of Osteoblastic MC3T3-E1 Cells through Glucose-induced Increase in the Receptor for AGEs.
• The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.
• The base-pairing ability of the base pair-mimic nucleosides.
• The reduction of proprioceptors in the mesencephalic trigeminal tract nucleus after neonatal masseteric nerve transection; effect of brain-derived neurotrophic factor.
• The uraemic toxin phenylacetic acid inhibits osteoblastic proliferation and differentiation: an implication for the pathogenesis of low turnover bone in chronic renal failure.
• Two components of chorismate mutase in Brevibacterium flavum.
• Understanding eye deformation in non-contact tonometry.
• [Impaired bone mineralization in calcium-sensing receptor (CaSR) knockout mice : the physiological action of CaSR in bone microenvironments]
• [Transcriptional regulation of CTP: phosphocholine cytidylyltransferase alpha in phospholipid biosynthesis]