Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon.

Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon. Research Abstract Details 

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Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon. Abstract Text:

Melanie D Bird,Chin-Fun Chu,Alison J Johnson,Gregg N Milligan,

Early clearance of a thymidine kinase-deficient strain of herpes simplex virus type 2 from the female genital tract required T-cell-produced gamma interferon (IFN-gamma). Transfer of activated CD8+ T cells to irradiated C57BL/6 mice resulted in rapid virus clearance, but clearance was greatly delayed in recipients deficient in the IFN-gamma receptor (IFN-gammaR). Early virus clearance was demonstrated in radiation chimeras in which IFN-gammaR expression was limited to parenchymal cells, but resolution was significantly delayed in chimeras deficient in IFN-gammaR expression and chimeras expressing IFN-gammaR only on hematopoietic cells. Together, these results suggest that early IFN-gamma-mediated protection was manifested mainly by stimulation of genital parenchymal cells.

Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon. Publishing Authors By Initials

MD Bird,CF Chu,AJ Johnson,GN Milligan,

For similar urogenital system: genitalia: genitalia, female: vagina research abstracts see: urogenital system: genitalia: genitalia, female: vagina research

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Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 81

Page Numbers: 423-6

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 25

MONTH: 10

YEAR: 2006

Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon. Keywords Mesh Terms:

KEYWORDS: Vagina

MESH TERMS: virology

Chemical & Substance for Abstract: Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon.

AFFILIATION: Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0436, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI42815

ACRONYM: AI

MEDLINETA: J Virol

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