Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses.

Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses. Research Abstract Details 

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Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses. Abstract Text:

Noelle K Polakos,Ingo Klein,Martin V Richter,Dietmar M Zaiss,Matthew Giannandrea,Ian N Crispe,David J Topham,

Interactions between the liver and CD8+ T cells can lead to tolerance, due in part to CD8+ T cell death. To test whether this was the case in an extrahepatic infection, we investigated the fate and effector capacity of intrahepatic CD8+ T cells during lung-restricted influenza infection in mice. Virus-specific T cells accumulated in livers without detectable intrahepatic presentation of viral Ags, and this accumulation was not restricted to the contraction phase, but was apparent as early as day 5. Intrahepatic influenza-specific cells were functionally similar to those recovered from the bronchioalveolar lavage, based on ex vivo cytokine production and specific target lysis. Both adoptive transfer of liver lymphocytes and orthotopic liver transplant of organs containing accumulated effector T cells revealed that activated CD8s from the liver were viable, expanded during reinfection, and generated a memory population that trafficked to lymphoid organs. Thus, intrahepatic CD8+ T cells re-enter circulation and generate functional memory, indicating that the liver does not uniformly incapacitate activated CD8+ T cells. Instead, it constitutes a substantial reservoir of usable Ag-specific effector CD8+ T cells involved in both acute and recall immune responses.

Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses. Publishing Authors By Initials

NK Polakos,I Klein,MV Richter,DM Zaiss,M Giannandrea,IN Crispe,DJ Topham,

For similar virus diseases: rna virus infections: orthomyxoviridae infections research abstracts see: virus diseases: rna virus infections: orthomyxoviridae infections research

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Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 201-10

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Jul

YEAR: 2007

Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses. Keywords Mesh Terms:

KEYWORDS: Orthomyxoviridae Infections

MESH TERMS: pathology

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Grant and Affiliation Information for Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses.

AFFILIATION: Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.

Country: United States

AGENCY: United States NIAID

GRANT: T32 AI 07285

ACRONYM: AI

MEDLINETA: J Immunol

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