Early dysregulation of cripto-1 and immunomodulatory genes in the cerebral cortex in a macaque model of neuroAIDS.

Early dysregulation of cripto-1 and immunomodulatory genes in the cerebral cortex in a macaque model of neuroAIDS. Research Abstract Details 

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Early dysregulation of cripto-1 and immunomodulatory genes in the cerebral cortex in a macaque model of neuroAIDS. Abstract Text:

Edward B Stephens,Mollie Jackson,Lisa Cui,Eric Pacyniak,Rajani Choudhuri,Christopher S Liverman,David S Salomon,Nancy E J Berman,

Human immunodeficiency virus type 1 (HIV-1) and related primate lentiviruses are known to enter the central nervous system (CNS) during the primary phase of infection. Neuroinvasion by simian immunodeficiency virus and simian human immunodeficiency virus (SHIV) is characterized by transient meningitis and astrocytosis. In this report, we used targeted cytokine cDNA arrays to analyze cortical brain tissue from four pig-tailed macaques inoculated for 2 weeks with pathogenic SHIV(50OLNV) and a normal age-matched pig-tailed macaque. Our results revealed that eight genes were significantly upregulated in all four macaques. These included: leukocyte interferon inducible peptide, corticotrophin releasing factor receptor 1, interleukin 6, CDW40 antigen, cysteine-rich fibroblast growth factor, neurotrophin 3, ciliary neurotrophin factor receptor and cripto-1. The upregulation of three of these genes was confirmed by reverse transcriptase PCR (RT-PCR). Since cripto-1 had not been previously identified within specific cell types within the primate central nervous system, we performed immunohistochemical studies, which revealed the presence of cripto-1 in neurons. RT-PCR studies demonstrated that cripto-1 mRNA was widely expressed in the CNS. These results indicate that immunomodulatory genes are upregulated during the primary phase of infection of the central nervous system. Cripto-1, which acts as a survival factor in tumor cells and may be neuroprotective, is expressed in neurons within the CNS and is upregulated during viral invasion.

Early dysregulation of cripto-1 and immunomodulatory genes in the cerebral cortex in a macaque model of neuroAIDS. Publishing Authors By Initials

EB Stephens,M Jackson,L Cui,E Pacyniak,R Choudhuri,CS Liverman,DS Salomon,NE Berman,

For similar viruses: rna viruses: retroviridae: lentivirus: lentiviruses, primate: simian immunodeficiency virus research abstracts see: viruses: rna viruses: retroviridae: lentivirus: lentiviruses, primate: simian immunodeficiency virus research

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Early dysregulation of cripto-1 and immunomodulatory genes in the cerebral cortex in a macaque model of neuroAIDS. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroscience letters

VOLUME: 410

Page Numbers: 94-9

Journal Abbreviation: Neurosci. Lett.

ISSN: 0304-3940

DAY: 3

MONTH: 11

YEAR: 2006

Early dysregulation of cripto-1 and immunomodulatory genes in the cerebral cortex in a macaque model of neuroAIDS. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7600130

Early dysregulation of cripto-1 and immunomodulatory genes in the cerebral cortex in a macaque model of neuroAIDS. Keywords Mesh Terms:

KEYWORDS: Simian immunodeficiency virus

MESH TERMS: pathogenicity

Chemical & Substance for Abstract: Early dysregulation of cripto-1 and immunomodulatory genes in the cerebral cortex in a macaque model of neuroAIDS. Information

Substance Name: Epidermal Growth Factor

Registry Number: 62229-50-9

Grant and Affiliation Information for Early dysregulation of cripto-1 and immunomodulatory genes in the cerebral cortex in a macaque model of neuroAIDS.

AFFILIATION: University of Kansas Medical Center, Anatomy & Cell Biology, 3901 Rainbow Blvd., Kansas City, KS 66160, United States.

Country: Ireland

AGENCY: United States NIMH

GRANT: MH61230

ACRONYM: MH

MEDLINETA: Neurosci Lett

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