Early detection of chemoradioresponse in esophageal carcinoma by 3'-deoxy-3'-3H-fluorothymidine using preclinical tumor models.

Early detection of chemoradioresponse in esophageal carcinoma by 3'-deoxy-3'-3H-fluorothymidine using preclinical tumor models. Research Abstract Details 

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Early detection of chemoradioresponse in esophageal carcinoma by 3'-deoxy-3'-3H-fluorothymidine using preclinical tumor models. Abstract Text:

Smith Apisarnthanarax,Mian M Alauddin,Firas Mourtada,Hisanori Ariga,Uma Raju,Osama Mawlawi,Dongmei Han,William G Bornmann,Jaffer A Ajani,Luka Milas,Juri G Gelovani,K S Clifford Chao,Smith Apisarnthanarax,Mian M Alauddin,Firas Mourtada,Hisanori Ariga,Uma Raju,Osama Mawlawi,Dongmei Han,William G Bornmann,Jaffer A Ajani,Luka Milas,Juri G Gelovani,K S Clifford Chao,

PURPOSE: Early identification of esophageal cancer patients who are responding or resistant to combined chemoradiotherapy may lead to individualized therapeutic approaches and improved clinical outcomes. We assessed the ability of 3'-deoxy-3'-(18)F-fluorothymidine positron emission tomography (FLT-PET) to detect early changes in tumor proliferation after chemoradiotherapy in experimental models of esophageal carcinoma. EXPERIMENTAL DESIGN: The in vitro and ex vivo tumor uptake of [(3)H]FLT in SEG-1 human esophageal adenocarcinoma cells were studied at various early time points after docetaxel plus irradiation and validated with conventional assessments of cellular proliferation [thymidine (Thd) and Ki-67] and [(18)F]FLT micro-PET imaging. Imaging-histologic correlation was determined by comparing spatial Ki-67 and [(18)F]FLT distribution in autoradiographs. Comparison with fluorodeoxyglucose (FDG) was done in all experiments. RESULTS: In vitro [(3)H]FLT and [(3)H]Thd uptake rapidly decreased in SEG-1 cells 24 hours after docetaxel with a maximal reduction of over 5-fold (P = 0.005). The [(3)H]FLT tumor-to-muscle uptake ratio in xenografts declined by 75% compared with baseline (P < 0.005) by 2 days after chemoradiotherapy, despite the lack of change in tumor size. In contrast, the decline of [(3)H]FDG uptake was gradual and less pronounced. Tumor uptake of [(3)H]FLT was more closely correlated with Ki-67 expression (r = 0.89, P < 0.001) than was [(3)H]FDG (r = 0.39, P = 0.08). Micro-PET images depicted similar trends in reduction of [(18)F]FLT and [(18)F]FDG tumor uptake. Autoradiographs displayed spatial correlations between [(18)F]FLT uptake and histologic Ki-67 distribution in preliminary studies. CONCLUSIONS: FLT-PET is suitable and more specific than FDG-PET for depicting early reductions in tumor proliferation that precede tumor size changes after chemoradiotherapy.

Early detection of chemoradioresponse in esophageal carcinoma by 3'-deoxy-3'-3H-fluorothymidine using preclinical tumor models. Publishing Authors By Initials

S Apisarnthanarax,MM Alauddin,F Mourtada,H Ariga,U Raju,O Mawlawi,D Han,WG Bornmann,JA Ajani,L Milas,JG Gelovani,KS Chao,S Apisarnthanarax,MM Alauddin,F Mourtada,H Ariga,U Raju,O Mawlawi,D Han,WG Bornmann,JA Ajani,L Milas,JG Gelovani,KS Chao,

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Early detection of chemoradioresponse in esophageal carcinoma by 3'-deoxy-3'-3H-fluorothymidine using preclinical tumor models. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Clinical cancer research : an official journal of

VOLUME: 12

Page Numbers: 4590-7

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ISSN: 1078-0432

DAY: 1

MONTH: Aug

YEAR: 2006

Early detection of chemoradioresponse in esophageal carcinoma by 3'-deoxy-3'-3H-fluorothymidine using preclinical tumor models. Information

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LANGUAGE: eng

NlmUniqueID: 9502500

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Grant and Affiliation Information for Early detection of chemoradioresponse in esophageal carcinoma by 3'-deoxy-3'-3H-fluorothymidine using preclinical tumor models.

AFFILIATION: Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA.

Country: United States

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MEDLINETA: Clin Cancer Res

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