Early blood profiles of virus infection in a monkey model for Lassa fever.

Early blood profiles of virus infection in a monkey model for Lassa fever. Research Abstract Details 

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Early blood profiles of virus infection in a monkey model for Lassa fever. Abstract Text:

Mahmoud M Djavani,Oswald R Crasta,Juan Carlos Zapata,Zhangjun Fei,Otto Folkerts,Bruno Sobral,Mark Swindells,Joseph Bryant,Harry Davis,C David Pauza,Igor S Lukashevich,Rasha Hammamieh,Marti Jett,Maria S Salvato,

Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after infection. Our goal was to identify molecular changes in blood that are related to disease progression. Rhesus macaques (Macaca mulatta) infected intravenously with a lethal dose of lymphocytic choriomeningitis virus (LCMV) provide a model for Lassa virus infection of humans. Blood samples taken before and during the course of infection were used to monitor gene expression changes that paralleled disease onset. Changes in blood showed major disruptions in eicosanoid, immune response, and hormone response pathways. Approximately 12% of host genes alter their expression after LCMV infection, and a subset of these genes can discriminate between virulent and non-virulent LCMV infection. Major transcription changes have been given preliminary confirmation by quantitative PCR and protein studies and will be valuable candidates for future validation as biomarkers for arenavirus disease.

Early blood profiles of virus infection in a monkey model for Lassa fever. Publishing Authors By Initials

MM Djavani,OR Crasta,JC Zapata,Z Fei,O Folkerts,B Sobral,M Swindells,J Bryant,H Davis,CD Pauza,IS Lukashevich,R Hammamieh,M Jett,MS Salvato,

For similar virus diseases: viremia research abstracts see: virus diseases: viremia research

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Early blood profiles of virus infection in a monkey model for Lassa fever. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of virology

VOLUME: 81

Page Numbers: 7960-73

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 23

MONTH: 05

YEAR: 2007

Early blood profiles of virus infection in a monkey model for Lassa fever. Information

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LANGUAGE: eng

NlmUniqueID: 113724

Early blood profiles of virus infection in a monkey model for Lassa fever. Keywords Mesh Terms:

KEYWORDS: Viremia

MESH TERMS: virology

Chemical & Substance for Abstract: Early blood profiles of virus infection in a monkey model for Lassa fever. Information

Substance Name: Cytokines

Registry Number: 0

Grant and Affiliation Information for Early blood profiles of virus infection in a monkey model for Lassa fever.

AFFILIATION: Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard St., Baltimore, MD 21201, USA.

Country: United States

AGENCY: United States NIAID

GRANT: U54 AI057168

ACRONYM: AI

MEDLINETA: J Virol

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