Early assessment of clinical response to concurrent chemoradiotherapy in head and neck carcinoma using fluoro-2-deoxy-d-glucose positron emission tomography.

Early assessment of clinical response to concurrent chemoradiotherapy in head and neck carcinoma using fluoro-2-deoxy-d-glucose positron emission tomography. Research Abstract Details 

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Early assessment of clinical response to concurrent chemoradiotherapy in head and neck carcinoma using fluoro-2-deoxy-d-glucose positron emission tomography. Abstract Text:

Choichi Horiuchi,Takahide Taguchi,Takafumi Yoshida,Goshi Nishimura,Mariko Kawakami,Yuji Tanigaki,Hideki Matsuda,Yasukazu Mikami,Takashi Oka,Tomio Inoue,Mamoru Tsukuda,

OBJECTIVES: The aim of this study is to assess the utility of FDG-PET in the evaluation of therapeutic effects at 4 weeks after the completion of the concurrent chemoradiotherapy (CCR) in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Thirty-one patients with previously untreated HNSCC were retrospectively investigated about FDG-PET, CT, MRI and biopsies of the carcinoma before and 4 weeks after the treatment. RESULTS: The results of pathological examinations after CCR showed 6 residual cases and 25 ones with a pathologically complete response (pCR). The specificity of FDG-PET was 80%, although the sensitivity was limited to 67%. CONCLUSIONS: FDG-PET has a high specificity but limited sensitivity to discriminate residual cancer from fibrosis or scar at 4 weeks after CCR. FDG-PET at 4 weeks after CCR was too early to perform because of limited sensitivity.

Early assessment of clinical response to concurrent chemoradiotherapy in head and neck carcinoma using fluoro-2-deoxy-d-glucose positron emission tomography. Publishing Authors By Initials

C Horiuchi,T Taguchi,T Yoshida,G Nishimura,M Kawakami,Y Tanigaki,H Matsuda,Y Mikami,T Oka,T Inoue,M Tsukuda,

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Early assessment of clinical response to concurrent chemoradiotherapy in head and neck carcinoma using fluoro-2-deoxy-d-glucose positron emission tomography. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Auris, nasus, larynx

VOLUME: 35

Page Numbers: 103-8

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ISSN: 0385-8146

DAY: 6

MONTH: 09

YEAR: 2007

Early assessment of clinical response to concurrent chemoradiotherapy in head and neck carcinoma using fluoro-2-deoxy-d-glucose positron emission tomography. Information

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LANGUAGE: eng

NlmUniqueID: 7708170

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AFFILIATION: Department of Otorhinolaryngology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

Country: Netherlands

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MEDLINETA: Auris Nasus Larynx

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