Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates.

Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates. Research Abstract Details 

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Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates. Abstract Text:

There is increasing evidence that obsessive-compulsive disorder (OCD) is mediated by genetic factors. Although the precise mechanism of inheritance is unclear, recent evidence has pointed towards the involvement of the serotonergic and dopaminergic systems in the disorder's development. Furthermore, early-onset OCD appears to be a subtype that exhibits distinct clinical features and that is associated with greater familial loading. In the present investigation, South African OCD patients (n=252) were stratified according to age of onset and were clinically assessed. Additionally, selected variants in genes encoding serotonergic and dopaminergic components were investigated in a Caucasian OCD subset (n=180). This subgroup was further stratified to evaluate the role that these candidate genes may play in the genetically homogeneous Afrikaner subset (n=80). Analysis of the clinical data revealed an association between early age of onset and an increased frequency of tics, Tourette's disorder, and trichotillomania (TTM). The genetic studies yielded statistically significant results when the allelic distributions of genetic variants in the dopamine receptor type 4 gene (DRD4) were analysed in the Caucasian OCD cohort. These data support a role for the dopaminergic system, which may be relevant to the development of early-onset OCD.

Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates. Publishing Authors By Initials

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychiatry research

VOLUME: 128

Page Numbers: 175-82

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 30

MONTH: Sep

YEAR: 2004

Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates. Information

Substance Name: Receptors, Dopamine D4

Registry Number: 137750-34-6

Grant and Affiliation Information for Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates.

AFFILIATION: MRC Unit on Anxiety and Stress Disorders, University of Stellenbosch, Medical School, PO Box 19063, Tygerberg 7505, South Africa. smjh@sun.ac.za

Country: Ireland

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MEDLINETA: Psychiatry Res

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