E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant.

E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant. Abstract Text:

Sally T Ishizaka,Lynn D Hawkins,Sally T Ishizaka,Lynn D Hawkins,

Safe and cost-effective adjuvants are a critical component to enhance the efficacy of subunit vaccines. Studies have demonstrated that modified natural lipid As derived from enterobacterial lipopolysaccharides, which are agonists of Toll-like receptor 4, are beneficial to vaccine performance. The synthetic phospholipid dimer, E6020, mimics the physicochemical and biological properties of many of the natural lipid As derived from gram-negative bacteria. Similar to its natural counterparts, E6020, which was discovered and developed by Eisai, agonizes Toll-like receptor 4, albeit in an attenuated fashion, eliciting an immunostimulatory response that is conducive to use as a vaccine adjuvant. The derivation of E6020, along with physicochemical properties and in vitro and in vivo studies of immunostimulation and adjuvant activity, are reviewed as a background to its imminent assessment in the clinic.

E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant. Publishing Authors By Initials

ST Ishizaka,LD Hawkins,ST Ishizaka,LD Hawkins,

For similar complex mixtures: biological products: vaccines research abstracts see: complex mixtures: biological products: vaccines research

PUBMED ID PMID:

MEDLINE DATE:

E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert review of vaccines

VOLUME: 6

Page Numbers: 773-84

Journal Abbreviation:

ISSN: 1744-8395

DAY: 28

MONTH: Oct

YEAR: 2007

E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101155475

E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant. Keywords Mesh Terms:

KEYWORDS: Vaccines

MESH TERMS: chemistry

Chemical & Substance for Abstract: E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant. Information

Substance Name: Vaccines

Registry Number: 0

Grant and Affiliation Information for E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant.

AFFILIATION: Eisai Research Institute, 4 Corporate Drive, Andover, MA 01742, USA. sally_ishizaka@eri.eisai.com

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Expert Rev Vaccines

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant Related Publications

• Are Cape floral clades the same age? Contemporaneous origins of two lineages in the genistoids s.l. (Fabaceae).
• Cavities and their response to treatment.
• Cellular autophagocytosis induced by deprivation of serum and amino acids in HeLa cells.
• Comparison of survival among eligible patients not enrolled versus enrolled in the Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma.
• Diversification of a large genus in a continental biodiversity hotspot: temporal and spatial origin of Muraltia (Polygalaceae) in the Cape of South Africa.
• E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant.
• Effects of light intensity and day-length on reproduction in the English sparrow.
• Feasibility of Free-breathing Respiratory Gated Liver Radiotherapy with MRI-derived Models.
• Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium.
• Healthcare costs of acute and chronic pain associated with a diagnosis of herpes zoster.
• Ileostomy and ulcerative colitis.
• Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies.
• Infantile myasthenia.
• Linking substance use and problem behavior across three generations.
• London's water-supplies.
• Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia.
• P43.12: Adnexal torsion at gestational limits of viability: is Doppler ultrasound helpful?
• Participants and Methods in AREDS Report No. 8.
• Pigment production by Serratia marcescens in liquid media.
• Positron emission tomography, positron emission tomography-computed tomography, and molecular imaging of the breast cancer patient.
• Presidon; a new sedative-hypnotic.
• Quantitative measurement of phosphatidylinositol 3,4,5-trisphosphate.
• R. HAWKINS, D.D.S.--THE INVISABLE DENTIST.
• Role of nitric oxide in classical conditioning of siphon withdrawal in Aplysia.
• Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy.
• TAT-Bim induces extensive apoptosis in cancer cells.
• The investigators' perspective on the collaborative ocular melanoma study.
• Time-dependent effects of free fatty acids on glucose effectiveness in type 2 diabetes.
• Uterine prolapse in second trimester of pregnancy; successful treatment of a case.
• Youth violence trajectories and proximal characteristics of intimate partner violence.