E-cadherin abnormalities resulting from CPG methylation promoter in metastatic and nonmetastatic oral cancer.

E-cadherin abnormalities resulting from CPG methylation promoter in metastatic and nonmetastatic oral cancer. Research Abstract Details 

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E-cadherin abnormalities resulting from CPG methylation promoter in metastatic and nonmetastatic oral cancer. Abstract Text:

Renato Vieira de Moraes,Denise Tostes Oliveira,Gilles Landman, de Carvalho, Caballero,Suely Nonogaki, Nishimoto,Luis Paulo Kowalski,Renato Vieira de Moraes,Denise Tostes Oliveira,Gilles Landman,Fabrício de Carvalho,Otávia Caballero,Suely Nonogaki,Inês Nishimoto,Luis Paulo Kowalski,Renato Vieira de Moraes,Denise Tostes Oliveira,Gilles Landman, de Carvalho, Caballero,Suely Nonogaki, Nishimoto,Luis Paulo Kowalski,

BACKGROUND.: This study aims to compare the alterations in the methylation profiles of E-cadherin in oral cancer, especially in tumors with lowest metatastic potential. METHODS.: Nine oral verrucous carcinomas (VCs), 20 oral well-differentiated squamous cell carcinomas without lymph node involvement (SCC-pN0), and 17 with lymph node involvement (SCC-pN+) were analyzed using methylation-specific polymerase chain reaction and immunohistochemical expression of E-cadherin gene. RESULTS.: The immunohistochemical expression of E-cadherin in VC was significantly higher (p = .016) when compared with SCC-pN0 and SCC-pN+ groups. The E-cadherin gene methylation was not correlated with its abnormal immunohistochemical expression in VC and SCC-pN0. All tumors of the SCC-pN+ group with unmethylated E-cadherin gene showed significant loss of E-cadherin immunoexpression (p = .044). CONCLUSIONS.: The E-cadherin gene methylation presence in tumors with lowest invasive and metastatic potential, such as VC, suggests the early involvement of this epigenetic event in the multistep progression of the oral carcinogenesis. (c) 2007 Wiley Periodicals, Inc. Head Neck, 2008.

E-cadherin abnormalities resulting from CPG methylation promoter in metastatic and nonmetastatic oral cancer. Publishing Authors By Initials

RV de Moraes,DT Oliveira,G Landman,F de Carvalho,O Caballero,S Nonogaki,I Nishimoto,LP Kowalski,RV de Moraes,DT Oliveira,G Landman,F de Carvalho,O Caballero,S Nonogaki,I Nishimoto,LP Kowalski,RV de Moraes,DT Oliveira,G Landman,F de Carvalho,O Caballero,S Nonogaki,I Nishimoto,LP Kowalski,

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E-cadherin abnormalities resulting from CPG methylation promoter in metastatic and nonmetastatic oral cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Head & neck

VOLUME: 30

Page Numbers: 85-92

Journal Abbreviation: Head Neck

ISSN: 1043-3074

DAY: 19

MONTH: Jan

YEAR: 2008

E-cadherin abnormalities resulting from CPG methylation promoter in metastatic and nonmetastatic oral cancer. Information

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LANGUAGE: eng

NlmUniqueID: 8902541

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AFFILIATION: Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Al. Dr. Octavio Pinheiro Brizolla, 9-75, 17012-901, Bauru, São Paulo, Brazil.

Country: United States

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MEDLINETA: Head Neck

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