Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA.

Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA. Abstract Text:

J A Bell,E Volpi,S Fujita,J G Cadenas,B B Rasmussen,

AIMS/HYPOTHESIS: An elevated lipid content within skeletal muscle cells is associated with the development of insulin resistance and type 2 diabetes mellitus. We hypothesised that in subjects with type 2 diabetes muscle malonyl-CoA (an inhibitor of fatty acid oxidation) would be elevated at baseline in comparison with control subjects and in particular during physiological hyperinsulinaemia with hyperglycaemia. Thus, fatty acids taken up by muscle would be shunted away from oxidation and towards storage (non-oxidative disposal). MATERIALS AND METHODS: Six control subjects and six subjects with type 2 diabetes were studied after an overnight fast and during a hyperinsulinaemic (0.5 mU kg(-1) min(-1)), hyperglycaemic clamp (with concurrent intralipid and heparin infusions) designed to increase muscle malonyl-CoA and inhibit fat oxidation. We used stable isotope methods, femoral arterial and venous catheterisation, and performed muscle biopsies to measure palmitate kinetics across the leg and muscle malonyl-CoA. RESULTS: Basal muscle malonyl-CoA concentrations were similar in control and type 2 diabetic subjects and increased (p<0.05) in both groups during the clamp (control, 0.14+/-0.05 to 0.24+/-0.05 pmol/mg; type 2 diabetes, 0.09+/-0.01 to 0.20+/-0.02 pmol/mg). Basal palmitate oxidation across the leg was not different between groups at baseline and decreased in both groups during the clamp (p<0.05). Palmitate uptake and non-oxidative disposal were significantly greater in the type 2 diabetic subjects at baseline and during the clamp (p<0.05). CONCLUSIONS/INTERPRETATION: Contrary to our hypothesis, the dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of muscle malonyl-CoA. However, elevated fatty acid uptake in type 2 diabetes may be a key contributing factor to the increase in fatty acids being shunted towards storage within muscle.

Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA. Publishing Authors By Initials

JA Bell,E Volpi,S Fujita,JG Cadenas,BB Rasmussen,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Diabetologia

VOLUME: 49

Page Numbers: 2144-52

Journal Abbreviation:

ISSN: 0012-186X

DAY: 26

MONTH: 07

YEAR: 2006

Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 6777

Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA.

AFFILIATION: Department of Kinesiology, University of Southern California, Los Angeles, CA, USA.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Diabetologia

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA Related Publications

• A Chronic Increase in Energy Expenditure Inhibits S6K1 and Reduces IRS-1 Serine Phosphorylation in Muscle: 540: May 30 10:30 AM - 10:45 AM.
• Association between intelligence and coronary heart disease mortality: a population-based cohort study of 682 361 Swedish men.
• Association of maternal obesity before conception with poor lactation performance.
• Blood Flow Restriction during Low-Intensity Resistance Exercise Increases Muscle Protein Synthesis through the mTOR Signaling Pathway: 666: May 31 8:00 AM 8:15 AM.
• Characterization of carbohydrate structures of bovine MUC15 and distribution of the mucin in bovine milk.
• Comparative proteomics of cell division mutants and wild-type of Synechococcus sp. strain PCC 7942.
• Cranial implant design using augmented reality immersive system.
• Distinct distribution of autosomal dominant spinocerebellar ataxia in the Mexican population.
• Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA.
• Experiences with carrier-mediated transport in liquid-phase microextraction.
• Extraction across supported liquid membranes by use of electrical fields.
• Genome-wide reprogramming in hybrids of somatic cells and embryonic stem cells.
• Haptic rendering of volumetric data for cranial implant modeling.
• Hysterectomy is associated with stress incontinence in women who previously had a transcervical endometrial resection.
• Impulse control disorders in adults with obsessive compulsive disorder.
• Inhibitory activities of bovine macromolecular whey proteins on rotavirus infections in vitro and in vivo.
• Inhibitory effects of human and bovine milk constituents on rotavirus infections.
• Late-onset obsessive compulsive disorder: clinical characteristics and psychiatric comorbidity.
• Mechanisms controlling death, survival and proliferation in a model unicellular eukaryote Tetrahymena thermophila.
• Microemulsion electrokinetic chromatography in suppressed electroosmotic flow environment. Separation of fat-soluble vitamins.
• Muscle Protein Synthesis is Enhanced Post-Resistance Exercise by Nutrient Stimulation of the mTOR Signaling Pathway: 873: June 1 1:30 PM - 1:45 PM.
• Olanzapine-induced weight gain and increased visceral adiposity is blocked by melatonin replacement therapy in rats.
• Opening rates of DNA hairpins: experiment and model.
• Postoperative cognitive dysfunction in patients with preoperative cognitive impairment: which domains are most vulnerable?
• Sexual obsessions and clinical correlates in adults with obsessive-compulsive disorder.
• Simulation of eye disease in virtual reality.
• Small RNAs controlling outer membrane porins.
• Stress distributions in diblock copolymers.
• Taboo thoughts and doubt/checking: a refinement of the factor structure for obsessive-compulsive disorder symptoms.
• The brown longitudinal obsessive compulsive study: treatments received and patient impressions of improvement.