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'Dyschromia in confetti' as a side effect of topical immunotherapy with diphenylcyclopropenone.

'Dyschromia in confetti' as a side effect of topical immunotherapy with diphenylcyclopropenone. Research Abstract Details 

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  • 'Dyschromia in confetti' as a side effect of topical immunotherapy with diphenylcyclopropenone. Abstract Text:

    "Dyschromia in confetti" is a pigmentary disturbance that so far has not been reported to have occurred during topical immunotherapy. In a group of 243 patients treated with diphenylcyclopropenone for alopecia areata, four patients showed a similar pattern of hyperpigmentation and hypopigmentation. In one patient the pigmentary disturbance was confined to the site of diphenylcyclopropenone application on the scalp. Besides dyschromic skin changes on her scalp, one patient had development of a hyperpigmentation on her forearms. In the remaining two patients, dyschromia in confetti became manifest exclusively in areas other than the scalp. This type of pigmentary disturbance appeared 4 to 14 months after the start of treatment, and it has remained unchanged in three patients during a follow-up period of 3 to 10 months. In one patient, the pigmentary changes disappeared when therapy was discontinued but recurred, albeit to a lesser extent, after treatment had been resumed. We conclude that dyschromia in confetti should be regarded as a possible, but probably rare, side effect of topical immunotherapy with diphenylcyclopropenone, especially in individuals with a rather dark complexion.

    'Dyschromia in confetti' as a side effect of topical immunotherapy with diphenylcyclopropenone. Publishing Authors By Initials

    For similar skin and connective tissue diseases: skin diseases: pigmentation disorders research abstracts see: skin and connective tissue diseases: skin diseases: pigmentation disorders research

    PUBMED ID PMID:

    MEDLINE DATE:

    'Dyschromia in confetti' as a side effect of topical immunotherapy with diphenylcyclopropenone. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Archives of dermatology

    VOLUME: 128

    Page Numbers: 518-20

    Journal Abbreviation: Arch Dermatol

    ISSN: 0003-987X

    DAY: 17

    MONTH: Apr

    YEAR: 1992

    'Dyschromia in confetti' as a side effect of topical immunotherapy with diphenylcyclopropenone. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 372433

    'Dyschromia in confetti' as a side effect of topical immunotherapy with diphenylcyclopropenone. Keywords Mesh Terms:

    KEYWORDS: Pigmentation Disorders

    MESH TERMS: chemically induced

    Chemical & Substance for Abstract: 'Dyschromia in confetti' as a side effect of topical immunotherapy with diphenylcyclopropenone. Information

    Substance Name: diphenylcyclopropenone

    Registry Number: 886-38-4

    Grant and Affiliation Information for 'Dyschromia in confetti' as a side effect of topical immunotherapy with diphenylcyclopropenone.

    AFFILIATION: Department of Dermatology, University of Nijmegen, The Netherlands.

    Country: UNITED STATES

    UNITED STATES Research PublicationUNITED STATES Research Publication

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    ACRONYM:

    MEDLINETA: Arch Dermatol

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