Dynein participates in chromosome segregation in fission yeast.

Dynein participates in chromosome segregation in fission yeast. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Dynein participates in chromosome segregation in fission yeast. Abstract Text:

Thibault Courtheoux,Guillaume Gay, Reyes,Sherilyn Goldstone,Yannick Gachet,Sylvie Tournier,Thibault Courtheoux,Guillaume Gay,Céline Reyes,Sherilyn Goldstone,Yannick Gachet,Sylvie Tournier,

BACKGROUND INFORMATION: In eukaryotic cells, proper formation of the spindle is necessary for successful cell division. For faithful segregation of sister chromatids, each sister kinetochore must attach to microtubules that extend to opposite poles (chromosome bi-orientation). At the metaphase-anaphase transition, cohesion between sister chromatids is removed, and each sister chromatid is pulled to opposite poles of the cell by microtubule-dependent forces. RESULTS: We have studied the role of the minus-end-directed motor protein dynein by analysing kinetochore dynamics in fission yeast cells deleted for the dynein heavy chain (Dhc1) or the light chain (Dlc1). In these mutants, we found an increased frequency of cells showing defects in chromosome segregation, which leads to the appearance of lagging chromosomes and an increased rate of chromosome loss. By following simultaneously kinetochore dynamics and localization of the checkpoint protein Mad2, we provide evidence that dynein function is not necessary for spindle-assembly checkpoint inactivation. Instead, we have demonstrated that loss of dynein function alters chromosome segregation and activates the Mad2-dependent spindle-assembly checkpoint. CONCLUSIONS: These results show an unexpected role for dynein in the control of chromosome segregation in fission yeast, most probably operating during the process of bi-orientation during early mitosis.

Dynein participates in chromosome segregation in fission yeast. Publishing Authors By Initials

T Courtheoux,G Gay,C Reyes,S Goldstone,Y Gachet,S Tournier,T Courtheoux,G Gay,C Reyes,S Goldstone,Y Gachet,S Tournier,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Dynein participates in chromosome segregation in fission yeast. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biology of the cell / under the auspices of the Eu

VOLUME: 99

Page Numbers: 627-37

Journal Abbreviation: Biol. Cell

ISSN: 1768-322X

DAY: 17

MONTH: Nov

YEAR: 2007

Dynein participates in chromosome segregation in fission yeast. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8108529

Dynein participates in chromosome segregation in fission yeast. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Dynein participates in chromosome segregation in fission yeast. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Dynein participates in chromosome segregation in fission yeast.

AFFILIATION: LBCMCP-CNRS UMR5088, Institut d'Exploration, Fonctionelle des Génomes (IFR109), Université Paul, Sabatier, 118 route de Narbonne, 31062 Toulouse, France.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biol Cell

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Dynein participates in chromosome segregation in fission yeast Related Publications

• Dynein participates in chromosome segregation in fission yeast.
• IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells.
• Long circulating superparamagnetic particles with high T2 relaxivity.
• Lost your orientation? Find your way with PtdIns(3,4,5)P3!
• Sister kinetochore recapture in fission yeast occurs by two distinct mechanisms, both requiring dam1 and klp2.
• Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.
• [Contribution of the third age]
• [Dosimetric study and first results of treatment of cancer of esophagus by telecobalt therapy.]
• [Human pasteurellosis.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Telecobalt therapy in cancer of esophagus after 2 years experience.]