Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.

Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Research Abstract Details 

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Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Abstract Text:

Ratna K Vadlamudi,Rozita Bagheri-Yarmand,Zhibo Yang,Seetharaman Balasenthil,Diep Nguyen,Aysegul A Sahin,Petra den Hollander,Rakesh Kumar,

We identified dynein light chain 1 (DLC1) as a physiologic substrate of p21-activated kinase 1 (Pak1). Pak1-DLC1 interaction plays an essential role in cell survival, which depends on Pak1's phosphorylation of DLC1 on Ser88. Pak1 associates with the complex of DLC1 and BimL, a proapoptotic BH3-only protein, and phosphorylates both proteins. Phosphorylation of BimL by Pak1 prevents it from interacting with and inactivation of Bcl-2, an antiapoptotic protein. Overexpression of DLC1 but not DLC1-Ser88Ala mutant promotes cancerous properties of breast cancer cells. DLC1 protein level is elevated in more than 90% of human breast tumors. The regulation of cell survival functions by Pak1-DLC1 interaction represents a novel mechanism by which a signaling kinase might regulate the cancerous phenotypes.

Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Publishing Authors By Initials

RK Vadlamudi,R Bagheri-Yarmand,Z Yang,S Balasenthil,D Nguyen,AA Sahin,P den Hollander,R Kumar,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: p21-activated kinases research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: p21-activated kinases research

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Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer cell

VOLUME: 5

Page Numbers: 575-85

Journal Abbreviation: Cancer Cell

ISSN: 1535-6108

DAY: 19

MONTH: Jun

YEAR: 2004

Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101130617

Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Keywords Mesh Terms:

KEYWORDS: p21-Activated Kinases

MESH TERMS: chemistry

Chemical & Substance for Abstract: Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Information

Substance Name: p21-Activated Kinases

Registry Number: EC 2.7.11.1

Grant and Affiliation Information for Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.

AFFILIATION: Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA90970

ACRONYM: CA

MEDLINETA: Cancer Cell

REFSOURCE: Cancer Cell. 204 Jul;6(1):101

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