Dynamical origin of independent spiking and bursting activity in neural microcircuits.

Dynamical origin of independent spiking and bursting activity in neural microcircuits. Research Abstract Details 

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Dynamical origin of independent spiking and bursting activity in neural microcircuits. Abstract Text:

Thomas Nowotny,Mikhail I Rabinovich,

The relationship between spiking and bursting dynamics is a key question in neuroscience, particularly in understanding the origins of different neural coding strategies and the mechanisms of motor command generation and neural circuit coordination. Experiments indicate that spiking and bursting dynamics can be independent. We hypothesize that different mechanisms for spike and burst generation, intrinsic neuron dynamics for spiking and a modulational network instability for bursting, are the origin of this independence. We tested the hypothesis in a detailed dynamical analysis of a minimal inhibitory neural microcircuit (motif) of three reciprocally connected Hodgkin-Huxley neurons. We reduced this high-dimensional dynamical system to a rate model and showed that both systems have identical bifurcations from tonic spiking to burst generation, which, therefore, does not depend on the details of spiking activity.

Dynamical origin of independent spiking and bursting activity in neural microcircuits. Publishing Authors By Initials

T Nowotny,MI Rabinovich,

For similar natural sciences: mathematics: nonlinear dynamics research abstracts see: natural sciences: mathematics: nonlinear dynamics research

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Dynamical origin of independent spiking and bursting activity in neural microcircuits. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Physical review letters

VOLUME: 98

Page Numbers: 128106

Journal Abbreviation: Phys. Rev. Lett.

ISSN: 0031-9007

DAY: 22

MONTH: 03

YEAR: 2007

Dynamical origin of independent spiking and bursting activity in neural microcircuits. Information

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LANGUAGE: eng

NlmUniqueID: 401141

Dynamical origin of independent spiking and bursting activity in neural microcircuits. Keywords Mesh Terms:

KEYWORDS: Nonlinear Dynamics

MESH TERMS: physiology

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Grant and Affiliation Information for Dynamical origin of independent spiking and bursting activity in neural microcircuits.

AFFILIATION: University of Sussex, Falmer, Brighton BN1 9QJ, UK. T.Nowotny@sussex.ac.uk

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS050945

ACRONYM: NS

MEDLINETA: Phys Rev Lett

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