[Dynamic study of anti-NS5 and ALT in post-transfusion hepatitis C]

[Dynamic study of anti-NS5 and ALT in post-transfusion hepatitis C] Research Abstract Details 

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[Dynamic study of anti-NS5 and ALT in post-transfusion hepatitis C] Abstract Text:

D Xu,H Lu,J Nu,Z Meng,D Shang,T Kang,

In order to study the character and dynamic changes of HCV NS5 antigen in post-transfusion hepatitis C, EIA was established with fusion protein, and different groups of population were investigated. The results showed the positive rate of whole blood donor, normal people, chronic hepatitis C patients and post transfusion hepatitis C patients is 0.0%, 1.66%, 50.7% and 70.5%, respectively. Serial blood samples of 25 cases of acute or chronic post-transfusion hepatitis C were detected, and the results indicated that the antibody of NS5 appeared relatively late, and the serum conversion time was 182.9 +/- 168.5 days. The anti-NS5 positive rate in 1, 3, 6, 12 and 24 months after HCV infection was 28%, 40%, 52%, 68% and 76%, respectively. The positive rate of anti-NS5 in sera with HCV RNA was 61.9%. Analysis on the appearance of antibody to the different antibody region of the gene, ALT and HCV RNA showed the dynamic changes of anti-NS5 were corresponding to the serum ALT in some cases, indicating antibody of NS5 appear later and may reflect the disease activity to some extent. The dynamic changes of anti-NS5 are of four kinds: transient positive, intermittent positive, persistent positive and persistent negative in during the two years period.

[Dynamic study of anti-NS5 and ALT in post-transfusion hepatitis C] Publishing Authors By Initials

D Xu,H Lu,J Nu,Z Meng,D Shang,T Kang,

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[Dynamic study of anti-NS5 and ALT in post-transfusion hepatitis C] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi

VOLUME: 11

Page Numbers: 344-7

Journal Abbreviation: Zhonghua Shi Yan He Lin Chuang

ISSN: 1003-9279

DAY: 24

MONTH: Dec

YEAR: 1997

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LANGUAGE: chi

NlmUniqueID: 9602873

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AFFILIATION: Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing.

Country: China

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MEDLINETA: Zhonghua Shi Yan He Lin Chuang

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