Dynamic simulation of bioprosthetic heart valves using a stress resultant shell model.

Dynamic simulation of bioprosthetic heart valves using a stress resultant shell model. Research Abstract Details 

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Dynamic simulation of bioprosthetic heart valves using a stress resultant shell model. Abstract Text:

Hyunggun Kim,Jia Lu,Michael S Sacks,Krishnan B Chandran,Hyunggun Kim,Jia Lu,Michael S Sacks,Krishnan B Chandran,

It is a widely accepted axiom that localized concentration of mechanical stress and large flexural deformation is closely related to the calcification and tissue degeneration in bioprosthetic heart valves (BHV). In order to investigate the complex BHV deformations and stress distributions throughout the cardiac cycle, it is necessary to perform an accurate dynamic analysis with a morphologically and physiologically realistic material specification for the leaflets. We have developed a stress resultant shell model for BHV leaflets incorporating a Fung-elastic constitutive model for in-plane and bending responses separately. Validation studies were performed by comparing the finite element predicted displacement and strain measures with the experimentally measured data under physiological pressure loads. Computed regions of stress concentration and large flexural deformation during the opening and closing phases of the cardiac cycle correlated with previously reported regions of calcification and/or mechanical damage on BHV leaflets. It is expected that the developed experimental and computational methodology will aid in the understanding of the complex dynamic behavior of native and bioprosthetic valves and in the development of tissue engineered valve substitutes.

Dynamic simulation of bioprosthetic heart valves using a stress resultant shell model. Publishing Authors By Initials

H Kim,J Lu,MS Sacks,KB Chandran,H Kim,J Lu,MS Sacks,KB Chandran,

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Dynamic simulation of bioprosthetic heart valves using a stress resultant shell model. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Annals of biomedical engineering

VOLUME: 36

Page Numbers: 262-75

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ISSN: 1521-6047

DAY: 29

MONTH: 11

YEAR: 2007

Dynamic simulation of bioprosthetic heart valves using a stress resultant shell model. Information

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LANGUAGE: eng

NlmUniqueID: 361512

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Grant and Affiliation Information for Dynamic simulation of bioprosthetic heart valves using a stress resultant shell model.

AFFILIATION: Department of Biomedical Engineering, College of Engineering, University of Iowa, 1402 SC, Iowa City, IA 52242, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-071814

ACRONYM: HL

MEDLINETA: Ann Biomed Eng

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