Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction.

Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction. Research Abstract Details 

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Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction. Abstract Text:

Keigo Nakamura,Satoshi Hirohata,Takashi Murakami,Toru Miyoshi,Kadir Demircan,Toshitaka Oohashi,Hiroko Ogawa,Kazuya Koten,Kenichi Toeda,Shozo Kusachi,Yoshifumi Ninomiya,Yasushi Shiratori,

Extracellular matrix (ECM)-degrading enzymes such as matrix metalloproteases (MMPs) play an essential role in the repair of infarcted tissue, which affects ventricular remodeling after myocardial infarction. ADAMTS1 (A disintegrin and metalloprotease with thrombospondin motifs), a newly discovered metalloprotease, was originally cloned from a cancer cell line, but little is known about its contribution to disease. To test the hypothesis that ADAMTS1 appears in infarcted myocardial tissue, we examined ADAMTS1 mRNA expression in a rat myocardial infarction model by Northern blotting, real-time RT-PCR and in situ hybridization. Normal endothelium expressed little ADAMTS1 mRNA, while normal myocardium expressed no detectable ADAMTS1 mRNA. Up-regulation of ADAMTS1 was demonstrated by Northern blot analysis and real-time RT-PCR at 3 h after coronary artery ligation. In situ hybridization revealed strong ADAMTS1 mRNA signals in the endothelium and myocardium in the infarcted heart, mainly in the infarct zone, at 3 h after myocardial infarction. The rapid and transient up-regulation of the ADAMTS1 gene in the ischemic heart was distinct from the regulatory patterns of other MMPs. Our study demonstrated that the ADAMTS1 gene is a new early immediate gene expressed in the ischemic endothelium and myocardium.

Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction. Publishing Authors By Initials

K Nakamura,S Hirohata,T Murakami,T Miyoshi,K Demircan,T Oohashi,H Ogawa,K Koten,K Toeda,S Kusachi,Y Ninomiya,Y Shiratori,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 136

Page Numbers: 439-46

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Oct

YEAR: 2004

Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: metabolism

Chemical & Substance for Abstract: Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction. Information

Substance Name: Metalloendopeptidases

Registry Number: EC 3.4.24.-

Grant and Affiliation Information for Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction.

AFFILIATION: Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan.

Country: Japan

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MEDLINETA: J Biochem

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