Dynamic functional and mechanical response of breast tissue to compression.

Dynamic functional and mechanical response of breast tissue to compression. Research Abstract Details 

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Dynamic functional and mechanical response of breast tissue to compression. Abstract Text:

Physiological tissue dynamics following breast compression offer new contrast mechanisms for evaluating breast health and disease with near infrared spectroscopy. We monitored the total hemoglobin concentration and hemoglobin oxygen saturation in 28 healthy female volunteers subject to repeated fractional mammographic compression. The compression induces a reduction in blood flow, in turn causing a reduction in hemoglobin oxygen saturation. At the same time, a two phase tissue viscoelastic relaxation results in a reduction and redistribution of pressure within the tissue and correspondingly modulates the tissue total hemoglobin concentration and oxygen saturation. We observed a strong correlation between the relaxing pressure and changes in the total hemoglobin concentration bearing evidence of the involvement of different vascular compartments. Consequently, we have developed a model that enables us to disentangle these effects and obtain robust estimates of the tissue oxygen consumption and blood flow. We obtain estimates of 1.9+/-1.3 mumol/100mL/min for OC and 2.8+/-1.7 mL/100mL/min for blood flow, consistent with other published values.

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Dynamic functional and mechanical response of breast tissue to compression. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Optics express

VOLUME: 16

Page Numbers: 16064-78

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ISSN: 1094-4087

DAY: 29

MONTH: Sep

YEAR: 2008

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LANGUAGE: eng

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Country: United States

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MEDLINETA: Opt Express

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