Dynamic development of the calyx of Held synapse.

Dynamic development of the calyx of Held synapse. Research Abstract Details 

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Dynamic development of the calyx of Held synapse. Abstract Text:

The calyx of Held is probably the largest synaptic terminal in the brain, forming a unique one-to-one connection in the auditory ventral brainstem. During early development, calyces have many collaterals, whose function is unknown. Using electrophysiological recordings and fast-calcium imaging in brain slices, we demonstrate that these collaterals are involved in synaptic transmission. We show evidence that the collaterals are pruned and that the pruning already begins 1 week before the onset of hearing. Using two-photon microscopy to image the calyx of Held in neonate rats, we report evidence that both axons and nascent calyces are structurally dynamic, showing the formation, elimination, extension, or retraction of up to 65% of their collaterals within 1 hour. The observed dynamic behavior of axons may add flexibility in the choice of postsynaptic partners and thereby contribute to ensuring that each principal cell eventually is contacted by a single calyx of Held.

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Dynamic development of the calyx of Held synapse. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 105

Page Numbers: 5603-8

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ISSN: 1091-6490

DAY: 28

MONTH: 03

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for Dynamic development of the calyx of Held synapse.

AFFILIATION: Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. a.rodriguezcontreras@erasmusmc.nl

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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