Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis.

Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis. Abstract Text:

J Ren,Y Huan,H Wang,Y-J Chang,H-T Zhao,Y-L Ge,Y Liu,Y Yang,J Ren,Y Huan,H Wang,Y-J Chang,H-T Zhao,Y-L Ge,Y Liu,Y Yang,

AIM: To investigate the diagnostic and differential diagnostic values of dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) in prostatic diseases, and to investigate the correlation between the parameters of SI-T curves and angiogenesis. MATERIALS AND METHODS: Twenty-one patients with proven prostatic carcinoma (Pca) and 29 patients with proven benign prostatic hyperplasia (BPH) were examined using DCE MRI. Diagnostic characteristics for differentiation were examined using threshold values for maximum peak time, enhancement degree, and enhancement rate. Then, the signal intensity-time curves (SI-T curves) were analysed, and the correlations between the parameters of SI-T curves and the expression levels of vascular endothelial growth factor (VEGF) and microvascular density (MVD) were investigated. All patents underwent prostatectomy. DCE MRI and histological findings were correlated. RESULTS: Pca showed stronger enhancement with an earlier peak time, higher enhancement, and enhancement rate (p<0.05). Regarding the type of SI-T curves, in the BPH group six were type A, 10 were type B, and 13 were type C, whereas in the Pca group, 14 were type A, six were type B, and only one was type C (Chi-square test, chi(2)=13.57, P<0.005). The VEGF and MVD expression levels of Pca were higher than those of BPH. Peak time was negatively correlated with the expression levels of VEGF and MVD, whereas the enhancement degree and enhancement rate showed positive correlations (Pearson correlation, p<0.05). CONCLUSION: Based on T2-weighted imaging, DCE MRI curves can help to differentiate benign from malignant prostate tissue. In the present study the type C curve was rarely seen with malignant disease, but these results need confirmation.

Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis. Publishing Authors By Initials

J Ren,Y Huan,H Wang,YJ Chang,HT Zhao,YL Ge,Y Liu,Y Yang,J Ren,Y Huan,H Wang,YJ Chang,HT Zhao,YL Ge,Y Liu,Y Yang,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical radiology

VOLUME: 63

Page Numbers: 153-9

Journal Abbreviation:

ISSN: 0009-9260

DAY: 19

MONTH: 11

YEAR: 2007

Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1306016

Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis.

AFFILIATION: Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Radiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis Related Publications

• Application of mucin quantitative competitive reverse transcription polymerase chain reaction in assisting the diagnosis of malignant pleural effusion.
• Aquaporin gene delivery to kidney.
• Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats.
• Late postoperative complication of the foldable lens implantation: opacification of the intraocular lenses.
• Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases.
• Tissue array technique for p53 expression in human ovarian neoplasms.
• [A case of cerebral schistosomiasis misdiagnosed as brain tumor]
• [Chromosome t (8; 21) and t (15; 17) in a patient with acute myeloid leukemia]
• [Construction of a subtracted cDNA library of differentially expressed genes in human normal liver tissue and primary hepatocellular carcinoma tissue]
• [Control genes of chondrocyte apoptosis in osteoarthritic articular cartilage]
• [Effects of cactus, alove veral, momorcica charantia on reducing the blood glucose of diabetic mice]
• [Force-dependent effects of interleukin-8 gene expression in endothelial cells exposed on fluid shear stress]
• [Human cytomegalovirus inhibits the proliferation of CFU-MK in vitro]
• [Immunorelated pancytopenia]
• [Intro-extro cranial approach treat serious post fronto-orbital fracture deformities]
• [Oxaliplatin in combination with LV5FU2 for advanced/metastatic gastric cancer-a multicenter study]
• [Patients of severe acute respiratory syndrome with hypoxemia treated by anisodamine]
• [Polylactic acid combined with recombinant human bone morphogenetic protein and basic fibroblast growth factor to repair the mandibular defects in rabbits]
• [Protection on proliferation of intestinal epithelial cells against hypoxia-reoxygenation through recombinant heat shock protein 70 adenovirus transfection]
• [Relationship between the changes of beta2-microglobulin in blood and urine and kidney involvements in children with pneumonia]
• [Research progress on the signal transduction and the molecular regulation of oocyte meiotic maturation]
• [Schistosomiasis investigation at 4 villages of Yangjiayuan during a flood in 1999]
• [Second-line Hycamtin in the treatment of lung cancer]
• [Sequential intensified immunosuppressive therapy combining with hematopoietic growth factors in the treatment of severe aplastic anemia]
• [Seventy degrees lateral decubital intraperiteanal laparoscopic adrenal surgery]
• [Studies on photochemical disinfectant enamelled-ware of toxicity experiments]
• [Study on the transformation from myelodysplastic syndromes into acute leukemias]
• [Surgical management of sacrococcygeal chordomas]
• [The genetic characteristic of HLA-DRB1 locus in the Jiangsu-Zhejiang-Shanghai Han population and a comparison of its frequency distribution with that of other populations]
• [The postburn changes in gastric mucosal blood flow and Na+-K+-ATPase activity and their effects on gastric transmucosal potential difference in severely scalded rats]