Dynamic colonisation by different Pneumocystis jirovecii genotypes in cystic fibrosis patients.

Dynamic colonisation by different Pneumocystis jirovecii genotypes in cystic fibrosis patients. Research Abstract Details 

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Dynamic colonisation by different Pneumocystis jirovecii genotypes in cystic fibrosis patients. Abstract Text:

M A Montes-Cano,C de la Horra,F J Dapena,I Mateos,V Friaza,N Respaldiza,F ,F J Medrano,E J Calderon,J M Varela,M A Montes-Cano,C de la Horra,F J Dapena,I Mateos,V Friaza,N Respaldiza,F ,F J Medrano,E J Calderon,J M Varela,

Although asymptomatic carriers of Pneumocystis jirovecii with cystic fibrosis (CF) have been described previously, the molecular epidemiology of P. jirovecii in CF patients has not yet been clarified. This study identified the distribution and dynamic evolution of P. jirovecii genotypes based on the mitochondrial large-subunit (mt LSU) rRNA gene. The mt LSU rRNA genotypes of P. jirovecii isolates in 33 respiratory samples from CF patients were investigated using nested PCR and direct sequencing. Three different genotypes were detected: 36.3% genotype 1 (85C/248C); 15.1% genotype 2 (85A/248C); 42.4% genotype 3 (85T/248C); and 6% mixed genotypes. Patients studied during a 1-year follow-up period showed a continuous colonisation/clearance cycle involving P. jirovecii and an accumulative tendency to be colonised with genotype 3.

Dynamic colonisation by different Pneumocystis jirovecii genotypes in cystic fibrosis patients. Publishing Authors By Initials

MA Montes-Cano,C de la Horra,FJ Dapena,I Mateos,V Friaza,N Respaldiza,F ,FJ Medrano,EJ Calderon,JM Varela,MA Montes-Cano,C de la Horra,FJ Dapena,I Mateos,V Friaza,N Respaldiza,F ,FJ Medrano,EJ Calderon,JM Varela,

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Dynamic colonisation by different Pneumocystis jirovecii genotypes in cystic fibrosis patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical microbiology and infection : the official

VOLUME: 13

Page Numbers: 1008-11

Journal Abbreviation: Clin. Microbiol. Infect.

ISSN: 1198-743X

DAY: 17

MONTH: 08

YEAR: 2007

Dynamic colonisation by different Pneumocystis jirovecii genotypes in cystic fibrosis patients. Information

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LANGUAGE: eng

NlmUniqueID: 9516420

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AFFILIATION: Department of Internal Medicine, Virgen Del Rocio University Hospital, Seville, Spain. marcoa.montes.exts@juntadeandalucia.es

Country: France

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MEDLINETA: Clin Microbiol Infect

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