Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release.

Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release. Research Abstract Details 

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Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release. Abstract Text:

Karla A Mark,Maria S Quinton,Shelley J Russek,Bryan K Yamamoto,

The vesicular glutamate (GLU) transporter (VGLUT1) is a critical component of glutamatergic neurons that regulates GLU release. Despite the likely role of GLU release in drug abuse pathology, there is no information that links VGLUT1 with drugs of abuse. This study provides the first evidence that methamphetamine (METH) alters the dynamic regulation of striatal VGLUT1 function and expression through a polysynaptic pathway. METH increases cortical VGLUT1 mRNA, striatal VGLUT1 protein in subcellular fractions, and the Vmax of striatal vesicular GLU uptake. METH also increases glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein in the crude vesicle fraction. METH-induced increases in cortical VGLUT1 mRNA, as well as striatal VGLUT1 and GAPDH, are GABA(A) receptor-dependent because they are blocked by GABA(A) receptor antagonism in the substantia nigra. These results show that VGLUT1 can be dynamically regulated via a polysynaptic pathway to facilitate vesicular accumulation of GLU for subsequent release after METH.

Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release. Publishing Authors By Initials

KA Mark,MS Quinton,SJ Russek,BK Yamamoto,

For similar proteins: carrier proteins: membrane transport proteins: ion pumps: antiporters: vesicular neurotransmitter transport proteins: vesicular glutamate transport proteins: vesicular glutamate transport protein 1 research abstracts see: proteins: carrier proteins: membrane transport proteins: ion pumps: antiporters: vesicular neurotransmitter transport proteins: vesicular glutamate transport proteins: vesicular glutamate transport protein 1 research

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Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 6823-31

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 20

MONTH: Jun

YEAR: 2007

Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release. Keywords Mesh Terms:

KEYWORDS: Vesicular Glutamate Transport Protein 1

MESH TERMS: secretion

Chemical & Substance for Abstract: Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release. Information

Substance Name: Glutamic Acid

Registry Number: 56-86-0

Grant and Affiliation Information for Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release.

AFFILIATION: Laboratory of Neurochemistry, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

Country: United States

AGENCY: United States NIDA

GRANT: DA07606

ACRONYM: DA

MEDLINETA: J Neurosci

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