DX16 is a novel SR protein phosphorylated by DOA.

DX16 is a novel SR protein phosphorylated by DOA. Research Abstract Details 

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DX16 is a novel SR protein phosphorylated by DOA. Abstract Text:

Yongqi Wan,Mingkuan Sun,Shanzhi Wang,Li Liu,Liudi Yuan,Wei Xie,Yongqi Wan,Mingkuan Sun,Shanzhi Wang,Li Liu,Liudi Yuan,Wei Xie,

The serine-arginine-rich (SR) proteins belong to a conserved splicing factor family that not only is essential for constitutive pre-mRNA splicing, but also plays important roles in regulation of alternative splicing. Dx16 is a member of SR protein family in Drosophila. In order to get more insight of dx16 function, we identified the proteins interacting with DX16 through yeast two-hybrid and GST-pull down assays. DX16 interacts with the U1 snRNP subunit CG7564, the SR protein RBP1 and the SR protein kinase DOA. The first and second serine-and arginine-rich regions of DOA are required for the interaction between DOA and DX16. DX16 could be phosphorylated by DOA in vitro and DX16 is highly phosphorylated in vivo. Immunofluorescence microscopy results reveal that doa and dx16 are both highly expressed in embryonic central nervous system. These results suggest that DX16 could be a novel SR protein phosphorylated by DOA and it may participate in the formation of splicing complex through its interactions with other splicing related proteins.

DX16 is a novel SR protein phosphorylated by DOA. Publishing Authors By Initials

Y Wan,M Sun,S Wang,L Liu,L Yuan,W Xie,Y Wan,M Sun,S Wang,L Liu,L Yuan,W Xie,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research

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DX16 is a novel SR protein phosphorylated by DOA. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular biochemistry

VOLUME: 307

Page Numbers: 177-83

Journal Abbreviation: Mol. Cell. Biochem.

ISSN: 0300-8177

DAY: 9

MONTH: 09

YEAR: 2007

DX16 is a novel SR protein phosphorylated by DOA. Information

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LANGUAGE: eng

NlmUniqueID: 364456

DX16 is a novel SR protein phosphorylated by DOA. Keywords Mesh Terms:

KEYWORDS: Tissue Distribution

MESH TERMS: metabolism

Chemical & Substance for Abstract: DX16 is a novel SR protein phosphorylated by DOA. Information

Substance Name: Protein-Serine-Threonine Kinases

Registry Number: EC 2.7.11.1

Grant and Affiliation Information for DX16 is a novel SR protein phosphorylated by DOA.

AFFILIATION: Department of Genetics and Developmental Biology, Southeast University Medical School, The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Nanjing, PR China.

Country: Netherlands

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MEDLINETA: Mol Cell Biochem

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