Duration of type I diabetes affects glucagon and glucose responses to insulin-induced hypoglycemia.

Duration of type I diabetes affects glucagon and glucose responses to insulin-induced hypoglycemia. Research Abstract Details 

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Duration of type I diabetes affects glucagon and glucose responses to insulin-induced hypoglycemia. Abstract Text:

The glucagon response to hypoglycemia, which fulfills a primary role toward restoring the plasma glucose level, is blunted or absent in most patients with type I diabetes. To identify predictive factors for this abnormality and for the capability of glycemic counterregulation, we investigated the relationship between the duration of diabetes and glucagon and glucose responses to insulin-induced hypoglycemia. In 18 type I diabetic patients with 1 through 28 years of disease who had no detectable autonomic neuropathy, individual glucagon increments after insulin hypoglycemia were inversely correlated with the duration of disease (r = -.53, P < .025). Patients with disease for ten or fewer years showed a glucagon rise that was lower than in controls but significantly higher than in patients with a duration of more than ten years. The plasma glucose rise after the nadir correlated with peak glucagon increments (r = .60, P < .01); eight of the nine patients with glycemic increments comparable to normals had had diabetes for ten years or less. Thus, having diabetes for more than ten years implied that not only were glucagon responses to insulin hypoglycemia severely compromised but also that the abrupt restoration of plasma glucose levels was impaired. These findings should be taken into account when establishing goals and modalities for tight metabolic control.

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Duration of type I diabetes affects glucagon and glucose responses to insulin-induced hypoglycemia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Western journal of medicine

VOLUME: 141

Page Numbers: 467-71

Journal Abbreviation: West. J. Med.

ISSN: 0093-0415

DAY: 4

MONTH: Oct

YEAR: 1984

Duration of type I diabetes affects glucagon and glucose responses to insulin-induced hypoglycemia. Information

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LANGUAGE: eng

NlmUniqueID: 410504

Duration of type I diabetes affects glucagon and glucose responses to insulin-induced hypoglycemia. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Duration of type I diabetes affects glucagon and glucose responses to insulin-induced hypoglycemia. Information

Substance Name: Glucagon

Registry Number: 9007-92-5

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Country: UNITED STATES

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MEDLINETA: West J Med

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