Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs.

Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Research Abstract Details 

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Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Abstract Text:

Nicolette H C Salmon Hillbertz,Magnus Isaksson,Elinor K Karlsson,Eva ,Gerli Rosengren Pielberg,Peter Savolainen,Claire M Wade,Henrik von Euler,Ulla Gustafson,Ake Hedhammar,Mats Nilsson,Kerstin Lindblad-Toh,Leif Andersson, Andersson,Nicolette H C Salmon Hillbertz,Magnus Isaksson,Elinor K Karlsson,Eva ,Gerli Rosengren Pielberg,Peter Savolainen,Claire M Wade,Henrik von Euler,Ulla Gustafson,Ake Hedhammar,Mats Nilsson,Kerstin Lindblad-Toh,Leif Andersson, Andersson,Nicolette H C Salmon Hillbertz,Magnus Isaksson,Elinor K Karlsson,Eva ,Gerli Rosengren Pielberg,Peter Savolainen,Claire M Wade,Henrik von Euler,Ulla Gustafson,Ake Hedhammar,Mats Nilsson,Kerstin Lindblad-Toh,Leif Andersson, Andersson,

The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.

Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Publishing Authors By Initials

NH Salmon Hillbertz,M Isaksson,EK Karlsson,E ,GR Pielberg,P Savolainen,CM Wade,H von Euler,U Gustafson,A Hedhammar,M Nilsson,K Lindblad-Toh,L Andersson,G Andersson,NH Salmon Hillbertz,M Isaksson,EK Karlsson,E ,GR Pielberg,P Savolainen,CM Wade,H von Euler,U Gustafson,A Hedhammar,M Nilsson,K Lindblad-Toh,L Andersson,G Andersson,NH Salmon Hillbertz,M Isaksson,EK Karlsson,E ,GR Pielberg,P Savolainen,CM Wade,H von Euler,U Gustafson,A Hedhammar,M Nilsson,K Lindblad-Toh,L Andersson,G Andersson,

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Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature genetics

VOLUME: 39

Page Numbers: 1318-20

Journal Abbreviation: Nat. Genet.

ISSN: 1546-1718

DAY: 30

MONTH: 09

YEAR: 2007

Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Information

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LANGUAGE: eng

NlmUniqueID: 9216904

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Grant and Affiliation Information for Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs.

AFFILIATION: Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences (SLU), Biomedical Centre, Box 597, SE-751 24 Uppsala, Sweden.

Country: United States

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MEDLINETA: Nat Genet

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