Duodenal mucosal protection by bicarbonate secretion and its mechanisms.

Duodenal mucosal protection by bicarbonate secretion and its mechanisms. Research Abstract Details 

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Duodenal mucosal protection by bicarbonate secretion and its mechanisms. Abstract Text:

S J Konturek,P C Konturek,T Pawlik,Z Sliwowski,W Ochma?ski,E G Hahn,S J Konturek,P C Konturek,T Pawlik,Z Sliwowski,W Ochma?ski,E G Hahn,

Proximal portion of duodenum is exposed to intermittent pulses of gastric H(+) discharged by the stomach. This review summarizes the mechanisms of duodenal mucosal integrity, mainly the role of mucus-alkaline secretion and the mucous barrier protecting surface epithelium against gastric H(+). The mucous barrier protects the leaky duodenal epithelium against each pulse of gastric H(+), which penetrates this barrier and diffuses into duodenocytes, but fails to damage them due to; a) an enhanced expression of cyclooxygenase-1 (COX-1), with release of protective prostaglandins (PG) and of nitric oxide (NO) synthase (NOS) with, however, production of NO, stimulating duodenal HCO(3)(-) secretion and b) the release of several neurotransmitters also stimulating HCO(3)(-) secretion such as vasoactive intestinal peptide (VIP), pituitary adenylate-cyclase activating polypeptide (PACAP), acetylcholine, melatonin, leptin and ghrelin released by enteric nerves and mucosal cells. At the apical duodenocyte membrane at least two HCO(3)(-)/Cl(-) anion exchangers operate in response to luminal H(+) to provide adequate extrusion of HCO(3)(-) into duodenal lumen. In the basolateral portion of duodenocyte membrane, both non-electrogenic (NBC) and electrogenic (NBC(n)) Na(+) HCO(3)(-) cotransporters are activated by the exposure to duodenal acidification, causing inward movement of HCO(3)(-) from extracellular fluid to duodenocytes. There are also at least three Na(+)/H(+) (NHE1-3) amiloride-sensitive exchangers, eliminating H(+)which diffused into these cells. The Helicobacter pylori (Hp) infection and gastric metaplasia in the duodenum with bacterium inoculating metaplastic mucosa and inhibiting HCO(3)(-) secretion by its endogenous inhibitor, asymmetric dimethyl arginine (ADMA), may result in duodenal ulcerogenesis.

Duodenal mucosal protection by bicarbonate secretion and its mechanisms. Publishing Authors By Initials

SJ Konturek,PC Konturek,T Pawlik,Z Sliwowski,W Ochma?ski,EG Hahn,SJ Konturek,PC Konturek,T Pawlik,Z Sliwowski,W Ochma?ski,EG Hahn,

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Duodenal mucosal protection by bicarbonate secretion and its mechanisms. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of physiology and pharmacology : an offici

VOLUME: 55 Suppl 2

Page Numbers: 5-17

Journal Abbreviation: J. Physiol. Pharmacol.

ISSN: 0867-5910

DAY: 20

MONTH: Jul

YEAR: 2004

Duodenal mucosal protection by bicarbonate secretion and its mechanisms. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Duodenal mucosal protection by bicarbonate secretion and its mechanisms.

AFFILIATION: Department of Physiology, Jagiellonian University Medical College, Cracow, Poland. mpkontur@cyf-kr.edu.pl

Country: Poland

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MEDLINETA: J Physiol Pharmacol

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