Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment.

Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment. Abstract Text:

Judith-Anne W Chapman,Naomi A Miller,H Lavina A Lickley,Jin Qian,William A Christens-Barry,Yuejiao Fu,Yan Yuan,David E Axelrod,Judith-Anne W Chapman,Naomi A Miller,H Lavina A Lickley,Jin Qian,William A Christens-Barry,Yuejiao Fu,Yan Yuan,David E Axelrod,

BACKGROUND: Previously, 50% of patients with breast ductal carcinoma in situ (DCIS) had more than one nuclear grade, and neither worst nor predominant nuclear grade was significantly associated with development of invasive carcinoma. Here, we used image analysis in addition to histologic evaluation to determine if quantification of nuclear features could provide additional prognostic information and hence impact prognostic assessments. METHODS: Nuclear image features were extracted from about 200 nuclei of each of 80 patients with DCIS who underwent lumpectomy alone, and received no adjuvant systemic therapy. Nuclear images were obtained from 20 representative nuclei per duct, from each of a group of 5 ducts, in two separate fields, for 10 ducts. Reproducibility of image analysis features was determined, as was the ability of features to discriminate between nuclear grades. Patient information was available about clinical factors (age and method of DCIS detection), pathologic factors (DCIS size, nuclear grade, margin size, and amount of parenchymal involvement), and 39 image features (morphology, densitometry, and texture). The prognostic effects of these factors and features on the development of invasive breast cancer were examined with Cox step-wise multivariate regression. RESULTS: Duplicate measurements were similar for 89.7% to 97.4% of assessed image features. For the pooled assessment with approximately 200 nuclei per patient, a discriminant function with one densitometric and two texture features was significantly (p < 0.001) associated with nuclear grading, and provided 78.8% correct jackknifed classification of a patient's nuclear grade. In multivariate assessments, image analysis nuclear features had significant prognostic associations (p

Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment. Publishing Authors By Initials

JA Chapman,NA Miller,HL Lickley,J Qian,WA Christens-Barry,Y Fu,Y Yuan,DE Axelrod,JA Chapman,NA Miller,HL Lickley,J Qian,WA Christens-Barry,Y Fu,Y Yuan,DE Axelrod,

For similar diagnosis: prognosis research abstracts see: diagnosis: prognosis research

PUBMED ID PMID:

MEDLINE DATE:

Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: BMC cancer

VOLUME: 7

Page Numbers: 174

Journal Abbreviation: BMC Cancer

ISSN: 1471-2407

DAY: 10

MONTH: 09

YEAR: 2007

Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100967800

Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment. Keywords Mesh Terms:

KEYWORDS: Prognosis

MESH TERMS: pathology

Chemical & Substance for Abstract: Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment.

AFFILIATION: National Cancer Institute of Canada Clinical Trials Group, Queen's University, 10 Stuart Street, Kingston, Ontario K7L 3N6, Canada. JChapman@ctg.queensu.ca

Country: England

AGENCY: United States NCI

GRANT: CA113004

ACRONYM: CA

MEDLINETA: BMC Cancer

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Ductal carcinoma in situ of the breast DCIS with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment Related Publications

• A SENSITIVE AND SPECIFIC ASSAY FOR THE ESTIMATION OF MONOAMINE OXIDASE.
• Arthroscopic visualization of the popliteus tendon.
• Atrophic nonunion of the clavicle: treatment by compression plate, lag-screw fixation and bone graft.
• Basal bodies, kinocilia and planar cell polarity.
• CIRCADIAN RHYTHM IN PINEAL SEROTONIN: EFFECT OF MONOAMINE OXIDASE INHIBITION AND RESERPINE.
• Catecholamines and hypertension.
• Deposition and fate of plutonium, uranium and their fission products inhaled as aerosols by rats and man.
• Differences and similarities in symptoms of hypophysectomy and tumors of the hypothalamic areas.
• Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment.
• ENZYMIC OXIDATION OF EPINEPHRINE TO ADRENOCHROME BY THE SALIVARY GLAND.
• Effect of ribonuclease on latent induced maltase in Saccharomyces oviformis.
• Fat, total cell and megakaryocyte content of sections of aspirated marrow of normal persons.
• Furan and tetrahydrofuran derivatives; the synthesis of the sulfonic acid analogs of oxybiotin and homooxybiotin.
• Health Problems in Industrialized Agriculture.
• Health problems in industrialized agriculture.
• Healthy older adult performance on a modified version of the Cognistat (NCSE): demographic issues and preliminary normative data.
• Hemodynamic manipulation in the neuro-intensive care unit: cerebral perfusion pressure therapy in head injury and hemodynamic augmentation for cerebral vasospasm.
• INHIBITION OF HISTAMINE METHYLATION IN VIVO BY DRUGS.
• Not Available
• Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats.
• Secretagogues elevate cytosolic calcium by stimulating cyclic AMP formation in a corticotropin secreting cell line.
• Secretory granule behaviour adjacent to the plasma membrane before and during exocytosis: total internal reflection fluorescence microscopy studies.
• THE FORMATION OF O-METHYLATED CATECHOLS BY MICROSOMAL HYDROXYLATION OF PHENOLS AND SUBSEQUENT ENZYMATIC CATECHOL O-METHYLATION. SUBSTRATE SPECIFICITY.
• The blood and bone marrow in patients with cirrhosis of the liver.
• The blood and bone marrow in patients with cirrhosis of the liver.
• The estimation of antipyrine in biological materials.
• The fate of acetophenetidin in man and methods for the estimation of acetophenetidin and its metabolites in biological material.
• Treatment of chronic leucemia with a folic acid antagonist.
• Use of folic acid antagonist in chronic leukemia.
• Wrist arthrodesis using a dynamic compression plate.